The farther, the safer: a manifesto for securely navigating synthetic species away from the old living world.
The farther, the safer: a manifesto for securely navigating synthetic species away from the old living world.
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DOI：
10.1007/s11693-009-9040-9
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Marliere, Philippe
中科院分区：
文献类型：
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作者：
Marliere, Philippe
生物技术已经经验性地确定，构建和评估变异基因和蛋白质比解释野生型大分子的出现和功能更容易。将这种建设性的方法系统化，合成生物学现在有望推断和组装全新的基因组、细胞和生态系统。这里有人认为，这一奋进所需的理论和计算工具完全缺失。然而，通过选择下的定向进化，通过添加、取代或去除元素和分子成分，使生物体在化学结构的基本水平上多样化，可能不需要这种工具。最重要的是，生命形式的化学多样化可以被设计成阻止合成物种和野生物种之间的代谢交叉喂养和遗传交叉对话，从而通过新型的遏制措施保护自然栖息地和人类健康。
Biotechnology has empirically established that it is easier to construct and evaluate variant genes and proteins than to account for the emergence and function of wild-type macromolecules. Systematizing this constructive approach, synthetic biology now promises to infer and assemble entirely novel genomes, cells and ecosystems. It is argued here that the theoretical and computational tools needed for this endeavor are missing altogether. However, such tools may not be required for diversifying organisms at the basic level of their chemical constitution by adding, substituting or removing elements and molecular components through directed evolution under selection. Most importantly, chemical diversification of life forms could be designed to block metabolic cross-feed and genetic cross-talk between synthetic and wild species and hence protect natural habitats and human health through novel types of containment.