Meta-analytic evidence for altered mesolimbic responses to reward in schizophrenia
Meta-analytic evidence for altered mesolimbic responses to reward in schizophrenia
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DOI：
10.1002/hbm.24049
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发表时间：
2018-07-01
影响因子：
4.8
通讯作者：
Nickl-Jockschat, Thomas
中科院分区：
文献类型：
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作者：
Chase, Henry W.;Loriemi, Polina;Nickl-Jockschat, Thomas
精神分裂症（SCZ）中奖赏相关神经回路功能障碍已被广泛报道，这可能有助于深入了解该疾病的动机和认知障碍。尽管之前已经对 SCZ 奖励学习范式进行了荟萃分析，但尚未对 SCZ 中的全脑坐标图进行荟萃分析。在本研究中，我们进行了激活似然估计（ALE）荟萃分析，并对已识别区域的功能连接和功能解码进行了后续分析。我们报告了一些突出的发现，扩展了该领域的先前工作。首先，在右腹侧纹状体中观察到奖励相关激活的改变，但这不仅仅是由 SCZ 组与健康对照组相比的低激活引起的。其次，该区域的特点是功能连接主要与外侧前额皮质和前补充运动区（preSMA）以及皮层下区域（例如丘脑）在 SCZ 中表现出结构缺陷。最后，尽管荟萃分析显示腹侧纹状体以外的区域没有显着改变，但与腹侧纹状体功能连接性较高的区域显示出更多的阈下病灶。总之，这些发现证实了 SCZ 腹侧纹状体功能的改变，但表明基于网络的方法可能有助于未来对该疾病的功能基础进行分析。
Dysfunction of reward-related neural circuitry in schizophrenia (SCZ) has been widely reported, and may provide insight into the motivational and cognitive disturbances that characterize the disorder. Although previous meta-analyses of reward learning paradigms in SCZ have been performed, a meta-analysis of whole-brain coordinate maps in SCZ alone has not been conducted. In this study, we performed an activation likelihood estimate (ALE) meta-analysis, and performed a follow-up analysis of functional connectivity and functional decoding of identified regions. We report several salient findings that extend prior work in this area. First, an alteration in reward-related activation was observed in the right ventral striatum, but this was not solely driven by hypoactivation in the SCZ group compared to healthy controls. Second, the region was characterized by functional connectivity primarily with the lateral prefrontal cortex and pre-supplementary motor area (preSMA), as well as subcortical regions such as the thalamus which show structural deficits in SCZ. Finally, although the meta-analysis showed no regions outside the ventral striatum to be significantly altered, regions with higher functional connectivity with the ventral striatum showed a greater number of subthreshold foci. Together, these findings confirm the alteration of ventral striatal function in SCZ, but suggest that a network-based approach may assist future analysis of the functional underpinnings of the disorder.