Recent developments in thyroid hormone metabolism: interpretation and significance of measurements of reverse T3, 3,3'T2, and thyroglobulin.
Recent developments in thyroid hormone metabolism: interpretation and significance of measurements of reverse T3, 3,3'T2, and thyroglobulin.
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甲状腺激素代谢的最新进展：反向 T3、3,3T2 和甲状腺球蛋白测量的解释和意义。
DOI：
10.1016/0026-0495(78)90028-8
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
Kenneth D. Burman
中科院分区：
文献类型：
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作者：
Kenneth D. Burman
特异性放射免疫分析的发展使得可以在正常和甲状腺经济改变状态下对血清和各种生物体液中的3，3 ′，5 ′-三碘甲状腺原氨酸（反向T3）、3，3 ′-二碘甲状腺原氨酸（3，3 ′T2）和甲状腺球蛋白进行测量。本文综述了反T3、3，3 ′ T2和甲状腺球蛋白的生理、动力学和代谢作用。目前，羊水和脐带血清中T3和3，3 ′ T2的测定可能有助于诊断胎儿或新生儿甲状腺功能障碍，血清甲状腺球蛋白的测定可能是分化型甲状腺癌患者治疗效果的重要指标。
The development of specific radioimmunoassays has allowed measurements of 3,3′,5′-triiodothyronine (reverse T3), 3,3′-diiodothyronine (3,3′T2), and thyroglobulin to be performed in serum and in various biologic fluids both in normal and in altered states of thyroidal economy. The physiology, kinetics, and metabolic actions of reverse T3, 3,3′T2and thyroglobulin are reviewed. Presently, it appears that reverse T3and 3,3′T2measurements in amniotic fluid and cord serum may potentially be useful in diagnosing fetal or neonatal thyroid dysfunction, and serum thyroglobulin measurements appear to be important as a measure of the efficacy of treatment of patients with differentiated thyroid carcinoma.