THE STRYCHNINE-BINDING SUBUNIT OF THE GLYCINE RECEPTOR SHOWS HOMOLOGY WITH NICOTINIC ACETYLCHOLINE-RECEPTORS
THE STRYCHNINE-BINDING SUBUNIT OF THE GLYCINE RECEPTOR SHOWS HOMOLOGY WITH NICOTINIC ACETYLCHOLINE-RECEPTORS
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DOI：
10.1038/328215a0
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发表时间：
1987-07-16
期刊：
影响因子：
64.8
通讯作者：
BETZ, H
中科院分区：
文献类型：
--
作者：
GRENNINGLOH, G;RIENITZ, A;BETZ, H
我们克隆并测序了大鼠甘氨酸受体的士的宁结合亚基的 cDNA，大鼠甘氨酸受体是中枢神经系统的神经递质门控氯离子通道蛋白。推导的多肽显示出与烟碱乙酰胆碱受体蛋白显着的结构和氨基酸序列同源性，表明存在编码神经递质门控离子通道的基因家族。
We have cloned and sequenced cDNAs of the strychnine-binding subunit of the rat glycine receptor, a neurotransmitter-gated chloride channel protein of the CNS. The deduced polypeptide shows significant structural and amino-acid sequence homology with nicotinic acetylcholine receptor proteins, indicating that there is a family of genes encoding neurotransmitter-gated ion channels.