The use of mitomycin C as an adjunctive treatment for equine ocular squamous cell carcinoma
The use of mitomycin C as an adjunctive treatment for equine ocular squamous cell carcinoma
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DOI：
10.1111/j.1751-0813.2006.tb13124.x
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发表时间：
2006-01-01
影响因子：
1.1
通讯作者：
Van Zyl, N
中科院分区：
文献类型：
--
作者：
Rayner, SG;Van Zyl, N
目的探讨局部应用丝裂霉素C作为CO2激光消融治疗马眼部鳞状细胞癌的替代辅助疗法的疗效。设计一项回顾性临床研究，在17个月的时间里，对8匹客户拥有的马的10只眼睛进行了眼部鳞状细胞癌的治疗。（2003年3月至2004年8月）每匹马被给予全身麻醉，以允许CO2激光消融病变。然后术中应用浓度为0.4 mg/mL的丝裂霉素C于患处1或5分钟。术后每日2次使用三抗生素眼药膏，每匹马全身应用非甾体类抗炎药治疗7天。结果治疗后复发3眼。其中两个已经撤退，没有进一步的迹象。应主人的要求，剩下的那只眼睛被去核了。总体而言，90%接受治疗的眼睛在治疗后至少11个月没有肿瘤。结论：在本病例中，丝裂霉素C系列似乎为目前用于治疗马眼部鳞状细胞癌的其他辅助疗法提供了一种有效的替代方案。
Objective To assess the effectiveness of topical mitomycin C application as an alternative adjunctive therapy to CO2 laser ablation in the treatment of equine ocular squamous cell carcinoma.Design A retrospective clinical study of eight client owned horses in which 10 affected eyes were treated for ocular squamous cell carcinoma over a 17 month period. (March 2003 to August 2004).Procedure Each horse was given a general anaesthetic to allow CO2 laser ablation of the lesion(s). Mitomycin C at a concentration of 0.4 mg/mL was then applied intraoperatively to the affected areas for 1 or 5 minutes. Postoperatively a triple antibiotic eye ointment was applied to the eye twice daily and each horse was treated with systemic non-steroidal anti-inflammatory drugs for 7 days.Results Recurrence following treatment was noted in three eyes. Two of these were retreated and no further signs developed. The remaining eye was enucleated at the request of the owner. Overall 90% of treated eyes appeared free of tumour a minimum of 11 months post treatment.Conclusion In this case series mitomycin C appeared to offer a valid alternative to other adjunctive therapies currently employed in the treatment of equine ocular squamous cell carcinoma.