Influence of vessel size, age and body mass index on the flow-mediated dilatation (FMD%) of the brachial artery
Influence of vessel size, age and body mass index on the flow-mediated dilatation (FMD%) of the brachial artery
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DOI：
10.1016/s0167-5273(00)00381-8
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发表时间：
2000-11-01
影响因子：
3.5
通讯作者：
Karsch, KR
中科院分区：
文献类型：
--
作者：
Schroeder, S;Enderle, MD;Karsch, KR
背景：无创检测肱动脉内皮功能障碍（艾德）是临床研究中广泛应用的方法。然而，尚不清楚测试结果是否受解剖血管尺寸、患者年龄、体重指数（BMI）或性别的影响。方法：测定122例（男88例，女34例）肱动脉血流介导的舒张功能（FMD%）。在静息状态、反应性充血期间和舌下给予硝酸甘油（GTN%）后，使用高分辨率超声（13 Mhz）测量FMD%。结果：静息时管腔直径范围为2.48 mm至6.33 mm（4.46+/-0.74 mm）。FMD%和GTN%与静息管腔直径呈负相关（r=-0.33，P
Background: The non-invasive determination of the endothelial dysfunction (ED) of the brachial artery is a widely used method in clinical research. It remained, however, unclear, whether the test-results are influenced by the anatomical vessel size, the patients age, body mass index (BMI) or gender. Methods: The flow-mediated vasodilatation (FMD%) of the brachial artery was determined in 122 consecutive (88 male, 34 female) patients. FMD% was measured using high resolution ultrasound (13 Mhz) at rest, during reactive hyperaemia and after the sublingual administration of glycerolnitrate (GTN%). Results: Lumen diameters at rest varied from 2.48 mm to 6.33 mm (4.46+/-0.74 mm). The extent of FMD% as well as of GTN% showed an inverse correlation to the resting lumen diameters (r=-0.33, P