Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats
Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats
复制标题
DOI：
10.1152/ajpendo.00487.2005
复制
发表时间：
2006-06-01
影响因子：
5.1
通讯作者：
Chen, Jan-Kan
中科院分区：
文献类型：
--
作者：
Su, Hui-Chen;Hung, Li-Man;Chen, Jan-Kan
能量代谢异常是糖尿病的特征之一。已经确定了两种类型的DM，1型和2型。大多数2型糖尿病患者最终成为胰岛素依赖型，因为胰岛的胰岛素分泌被耗尽。在本研究中，我们发现白藜芦醇（3，5，4 '-三羟基二苯乙烯）具有降血糖和降血脂的作用，在链脲佐菌素诱导的糖尿病（STZDM）大鼠。在白藜芦醇处理的STZ-DM大鼠中，与溶剂处理的大鼠相比，第14天的血糖浓度降低了25.3 +/-4.2%，甘油三酯浓度降低了50.2 +/- 3.2%。在STZ-烟酰胺DM大鼠中，与溶剂处理的大鼠相比，第14天的血糖浓度降低了20.3 +/-4.2%，甘油三酯浓度降低了33.3 +/-2.2%。白藜芦醇给药可改善常见的DM症状，如体重减轻、多食和烦渴。在STZ-烟酰胺DM大鼠中，白藜芦醇给药显著降低胰岛素分泌并延迟胰岛素抵抗的发生。进一步的研究表明，白藜芦醇处理可以刺激肝细胞、脂肪细胞和骨骼肌的葡萄糖摄取以及肝糖原的合成。因为在胰岛素应答细胞中存在最佳量的胰岛素时葡萄糖摄取的刺激没有减弱，所以白藜芦醇的抗高血糖作用似乎通过与胰岛素不同的机制起作用。
Aberrant energy metabolism is one characteristic of diabetes mellitus (DM). Two types of DM have been identified, type 1 and type 2. Most of type 2 DM patients eventually become insulin dependent because insulin secretion by the islets of Langerhans becomes exhausted. In the present study, we show that resveratrol ( 3,5,4'- trihydroxylstilbene) possesses hypoglycemic and hypolipidemic effects in streptozotocin-induced DM (STZDM) rats. In resveratrol-treated STZ-DM rats, the plasma glucose concentration on day 14 was reduced by 25.3 +/- 4.2%, and the triglyceride concentration was reduced by 50.2 +/- 3.2% compared with the vehicle-treated rats. In STZ- nicotinamide DM rats, the plasma glucose concentration on day 14 was reduced by 20.3 +/- 4.2%, and the triglyceride concentration was reduced by 33.3 +/- 2.2% compared with the vehicle- treated rats. Resveratrol administration ameliorates common DM symptoms, such as body weight loss, polyphagia, and polydipsia. In STZ- nicotinamide DM rats, resveratrol administration significantly decreased insulin secretion and delayed the onset of insulin resistance. Further studies showed that glucose uptake by hepatocytes, adipocytes, and skeletal muscle and hepatic glycogen synthesis were all stimulated by resveratrol treatment. Because the stimulation of glucose uptake was not attenuated in the presence of an optimal amount of insulin in insulin- responsive cells, the antihyperglycemic effect of resveratrol appeared to act through a mechanism( s) different from that of insulin.