Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan
Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan
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DOI：
10.3389/fendo.2020.00478
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发表时间：
2020-07-14
影响因子：
5.2
通讯作者：
Wu, Xiaohui
中科院分区：
文献类型：
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作者：
Liu, Zeming;Li, Jinpeng;Wu, Xiaohui
目的：本研究旨在调查武汉市2019冠状病毒病（COVID-19）糖尿病患者的临床病程和结局。方法：本研究纳入了雷神山医院确诊的COVID-19连续患者1,880例。我们收集并分析了他们的数据，包括人口统计学数据、合并症史、临床症状、实验室检查、胸部计算机断层扫描（CT）图像、治疗方案和生存率。结果：重症和危重型COVID-19病例中糖尿病患者的比例高于轻度或一般病例（89.2%，10.8vs. 0%，p = 0.001）。然而，在随访期间，糖尿病患者和非糖尿病患者没有表现出差异（p= 0.993）。有或无糖尿病患者的死亡率分别为2.9%（n= 4）和1.1%（n= 9）（p= 0.114）。单因素和多因素考克斯回归分析和Kaplan-Meier曲线显示糖尿病患者和非糖尿病患者之间没有任何统计学显著性差异（均P> 0.05）。结论：我们的研究结果表明，糖尿病对COVID-19患者的预后没有影响，但与其临床病程呈负相关。这些结果可能有助于临床医生管理COVID-19糖尿病患者。
Aims:This study aimed to investigate the clinical courses and outcomes of diabetes mellitus patients with coronavirus disease 2019 (COVID-19) in Wuhan. Methods:This study enrolled 1,880 consecutive patients with confirmed COVID-19 in Leishenshan Hospital. We collected and analyzed their data, including demographic data, history of comorbidity, clinical symptoms, laboratory tests, chest computed tomography (CT) images, treatment options, and survival. Results:The percentages of patients with diabetes among the severe and critical COVID-19 cases were higher than those among the mild or general cases (89.2%, 10.8 vs. 0%,p= 0.001). However, patients with and without diabetes showed no difference in the follow-up period (p= 0.993). The mortality rate in patients with or without diabetes was 2.9% (n= 4) and 1.1% (n= 9), respectively (p= 0.114). Univariate and multivariate Cox regression analyses and the Kaplan-Meier curves did not show any statistically significant differences between patients with and without diabetes (allp> 0.05). Conclusions:Our study results suggested that diabetes had no effect on the prognosis of COVID-19 patients but had a negative association with their clinical courses. These results may be useful for clinicians in the management of diabetic patients with COVID-19.