COMPARATIVE-STUDY OF ANTI-ALLERGIC EFFECTS OF DISODIUM BAICALEIN 6-PHOSPHATE (BPS) AND DISODIUM-CROMOGLYCATE (DSCG)
COMPARATIVE-STUDY OF ANTI-ALLERGIC EFFECTS OF DISODIUM BAICALEIN 6-PHOSPHATE (BPS) AND DISODIUM-CROMOGLYCATE (DSCG)
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DOI：
10.1254/jjp.27.31
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发表时间：
1977-01-01
期刊：
影响因子：
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通讯作者：
SAKAMOTO, K
中科院分区：
文献类型：
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作者：
KODA, A;WATANABE, S;SAKAMOTO, K
对黄芩素的可溶性衍生物黄芩素6-磷酸二钠（BPS）和色甘酸二钠（DSCG）对速发型变态反应的影响进行了比较研究。BPS不仅能抑制反应素抗体介导的反应，如猴肺抗原诱导的介质释放、大鼠被动皮肤过敏反应和反应素抗体介导的肥大细胞脱颗粒，而且能抑制非反应素抗体介导的反应，如卵清蛋白致敏的豚鼠肺介质释放和抗Ig E引起的人肺介质释放。该试剂不影响二硝基苯化蛔虫提取物加百日咳杆菌致敏大鼠肺介质释放。DSCG显示出作为反应素抗体介导的反应的抑制剂的特性。反应素抗体的功能位点与DSCG在2-色酮核之间的一定距离处固定良好，而IgG的功能位点容易与黄芩素或BPS的2个分子固定。
A comparative study was carried out on the effects of a soluble derivative of baicalein, disodium baicalein 6-phosphate (BPS) and disodium cromoglycate (DSCG) on the immediate type allergic reactions. BPS not only inhibited reaginic antibody-mediated reactions including antigen-induced mediator release from monkey [Macaca irus] lung, homologous PCA [passive cutaneous anaphylaxis] in rats and reaginic antibody-mediated degranulation of mast cell, but also non-reaginic antibody-mediated reactions such as mediator release from guinea pig lung sensitized with ovalbumin and that from human lung caused by anti-Ig[immunoglobulin]E. The agent did not affect the mediator release from lung of rats sensitized with dinitrophenylated Ascaris extract plus Bordetella pertussis. DSCG showed characteristic properties as an inhibitor of reaginic antibody-mediated reaction. The functional site of reaginic antibody is well fixed with DSCG at a definite distance between the 2-chromone-nuclei while that of IgG is readily fixed with the 2 molecules of baicalein or BPS.