Septin GTPases spatially guide microtubule organization and plus end dynamics in polarizing epithelia.
Septin GTPases spatially guide microtubule organization and plus end dynamics in polarizing epithelia.
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DOI：
10.1083/jcb.201102076
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发表时间：
2011-07-25
期刊：
影响因子：
--
通讯作者：
Spiliotis ET
中科院分区：
文献类型：
--
作者：
Bowen JR;Hwang D;Bai X;Roy D;Spiliotis ET
Filamentous and microtubule-associated septin GTPases guide the reorganization of the microtubule network during epithelial cell polarization. Establishment of epithelial polarity requires the reorganization of the microtubule (MT) cytoskeleton from a radial array into a network positioned along the apicobasal axis of the cell. Little is known about the mechanisms that spatially guide the remodeling of MTs during epithelial polarization. Septins are filamentous guanine triphosphatases (GTPases) that associate with MTs, but the function of septins in MT organization and dynamics is poorly understood. In this paper, we show that in polarizing epithelia, septins guide the directionality of MT plus end movement by suppressing MT catastrophe. By enabling persistent MT growth, two spatially distinct populations of septins, perinuclear and peripheral filaments, steer the growth and capture of MT plus ends. This navigation mechanism is essential for the maintenance of perinuclear MT bundles and for the orientation of peripheral MTs as well as for the apicobasal positioning of MTs. Our results suggest that septins provide the directional guidance cues necessary for polarizing the epithelial MT network.
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影响因子：
3.3
作者：
Applewhite DA;Grode KD;Keller D;Zadeh AD;Slep KC;Rogers SL
通讯作者：
Rogers SL
影响因子：
11.6
作者：
Dixit, R;Cyr, R
通讯作者：
Cyr, R
DOI：
10.1083/jcb.109.6.2817
发表时间：
1989-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bacallao R;Antony C;Dotti C;Karsenti E;Stelzer EH;Simons K
通讯作者：
Simons K
DOI：
10.1083/jcb.201006044
发表时间：
2010-08-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Jaulin F;Kreitzer G
通讯作者：
Kreitzer G
影响因子：
2.7
作者：
Kojima, SI;Vignjevic, D;Borisy, GG
通讯作者：
Borisy, GG