Duration of action of a single, early oral application of chlorhexidine on oral microbial flora in mechanically ventilated patients: A pilot study
Duration of action of a single, early oral application of chlorhexidine on oral microbial flora in mechanically ventilated patients: A pilot study
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DOI：
10.1016/j.hrtlng.2003.12.004
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发表时间：
2004-03-01
期刊：
影响因子：
2.8
通讯作者：
Ward, KR
中科院分区：
文献类型：
--
作者：
Grap, MJ;Munro, CL;Ward, KR
目的：探讨插管后早期口服葡萄糖酸氯己定对口腔微生物区系及呼吸机相关性肺炎的影响。方法：将34例气管插管患者随机分为3组，分别采用喷雾、拭子和对照组。在研究入院时、12、24、48和72小时进行口腔培养，而在研究入院时、48小时和72小时记录临床肺部感染评分(CPIS)。结果：口腔培养分数(生长较少)仅在治疗组(拭子和喷雾)中发现；对照组没有发现减少。在联合治疗组中有一种阳性培养较少的趋势。对照组的平均CPIS增加到一个指示的水平。肺炎(4.7~6.6)，而治疗I组CPIS仅轻微上升(5.17~5.57)。结论：数据趋势提示插管后早期应用葡萄糖酸氯己定可减轻或延缓呼吸机相关性肺炎的发展。
OBJECTIVE: The purpose of this study was to describe the effect of an early post-intubation oral application of chlorhexidine gluconate on oral microbial flora and ventilator-associated pneumonia.METHODS: Thirty-four intubated patients were randomly assigned to chlorhexidine gluconate by spray or swab or to control group. Oral cultures were done at study admission, 12, 24, 48, and 72 hours, whereas the Clinical Pulmonary infection Score (CPIS) was documented at study admission, 48, and 72 hours.RESULTS: Reductions in oral culture scores (less growth) were only,found in the treatment groups (swab and spray); no reduction was found in the control group. There was a trend for fewer positive cultures in the combined treatment groups. The mean CPIS for the control group increased to a level indicating. pneumonia (4.7 to 6.6), whereas the CPIS for the treatment group I increased only slightly (5.17 to 5.57).CONCLUSIONS: Trends in the data suggest that use of chlorhexidine gluconate in the early postintubation period may mitigate or delay the development of ventilator-associated pneumonia.