Coenzyme Q, oxidative stress and aging
Coenzyme Q, oxidative stress and aging
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DOI：
10.1016/j.mito.2007.03.006
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发表时间：
2007-06-01
期刊：
影响因子：
4.4
通讯作者：
Forster, Michael J.
中科院分区：
文献类型：
--
作者：
Sohal, Rajindar S.;Forster, Michael J.
辅酶 Q (CoQ) 在线粒体中具有三个明显的功能，即 (i) 电子传递链中还原当量的转移，(ii) 超氧阴离子自由基 O-2(.-) 的产生，以及 (iii) 自由基的猝灭。本综述的主要目的是讨论相对较长时间摄入 CoQ(10) 对线粒体呼吸的影响 动物的能力、氧化应激指标和寿命，以及是否可以通过 CoQ(10) 给药来改变衰老过程的整体进展这一更广泛的问题。对不同哺乳动物物种的比较研究表明，线粒体超氧阴离子自由基生成速率与线粒体CoQ(9)含量成正相关，与CoQ(10)含量成反比，特别是 CoQ(10) 与线粒体膜蛋白结合。与历史观点相反，小鼠和大鼠的膳食补充 CoQ(10) 已被证明可以增加线粒体和各种组织匀浆中的内源性 CoQ 含量 (CoQ(9) + CoQ(10))，尽管程度不同。摄入 CoQ(10) 会导致内源性 CoQ9 升高，即 小鼠和大鼠中的主要同源物。在我们的研究中，没有迹象表明 CoQ(10) 摄入量具有明显的效果，可以反映线粒体呼吸活性的增强、抗氧化能力和促氧化作用的增强或寿命的延长。不能排除 CoQ(10) 摄入通过尚未阐明的机制影响某些其他生物功能的可能性，因为 CoQ 已被证明 广泛改变小鼠的基因表达。(c) 2007 Elsevier B.V. 和线粒体研究协会。保留所有权利。
Coenzyme Q (CoQ has three well-characterized functions in mitochondria, namely (i) transfer of reducing equivalents in the electron transport chain, (ii) generation of superoxide anion radical, O-2(.-), and (iii) quenching of free radicals. The main purpose of this review is to discuss the effects of CoQ(10) intake for relatively prolonged periods on mitochondrial respiratory capacity, indicators of oxidative stress, and life span of animals, in context of the broader issue of whether or not the overall progression of the aging process can be modified by CoQ(10) administration. Comparative studies on different mammalian species have indicated that the rate of mitochondrial superoxide anion radical generation is directly correlated with mitochondrial CoQ(9) content and inversely related to amounts of CoQ(10), particularly the CoQ(10) bound to mitochondrial membrane proteins. Contrary to the historical view, dietary supplementation of mice and rats with CoQ(10) has been demonstrated to augment the endogenous CoQ content (CoQ(9) + CoQ(10)) in mitochondria and homogenates of various tissues, albeit to varying extent. Ingestion of CoQ(10) results in the elevation of endogenous CoQ9, the predominant homologue in mice and rats. In our studies, there was no indication of a discernable effect of CoQ(10) intake reflecting enhancement of mitochondrial respiratory activity, antioxidant capacity and pro-oxidant potentiation or prolongation of life span. The possibility that CoQ(10) intake affects certain other biological functions by as yet unelucidated mechanisms cannot be ruled out as CoQ has been shown to broadly alter gene expression in mice.(c) 2007 Elsevier B.V. and Mitochondria Research Society. All rights reserved.