Risk factors of thyroid cancer among women in Tokai, Japan.
Risk factors of thyroid cancer among women in Tokai, Japan.
复制标题
日本东海女性甲状腺癌的危险因素。
作者：
T. Takezaki;K. Hirose;M. Inoue;Nobuyuki Hamajima;Tetsuo Kuroishi;S. Nakamura;Takashi Koshikawa;Hidehiro Matsuura;K. Tajima
为了分析日本女性甲状腺癌的危险因素，这些女性通常比欧洲人消耗更多的碘，我们在日本名古屋的爱知癌症中心医院（ACCH）进行了一项以医院为基础的病例参考研究。94例年龄在20-79岁之间的甲状腺乳头状癌或滤泡状癌女性患者和22，666例无癌症的女性门诊患者。既往有良性甲状腺肿块或甲状腺肿（OR = 13.9）和甲状腺功能亢进（OR = 5.0）病史者，甲状腺癌的OR增加。甲状腺癌患者喝咖啡的频率较低（OR = 0.5），分娩经验多于对照组（≥ 3次; OR = 2.5）。西式早餐（OR = 0.5）也降低了OR。多变量分析显示，既往甲状腺疾病史（OR = 4.3）与甲状腺癌风险呈正相关，每天饮用咖啡（OR = 0.6）可降低甲状腺癌风险。这些结果表明，在日本，甲状腺癌相关因素也可能与甲状腺癌的风险有关。为了澄清日本食品的风险，需要进行另一项比较研究，包括国家和个人之间碘摄入量的详细信息。
To analyze the risk factors of thyroid cancer among Japanese women who generally consume much more iodine than Europeans, we conducted a hospital-based case-referent study at Aichi Cancer Center Hospital (ACCH) in Nagoya, Japan. Ninety-four female patients aged between 20-79 years with papillary or follicular carcinoma of the thyroid, and 22,666 female outpatients without cancer were used. Past history of benign thyroid mass or goiter (odds ratio: OR = 13.9) and hyperthyroidism (OR = 5.0) showed increased ORs of thyroid cancer. Thyroid cancer cases consumed coffee less frequently (OR = 0.5) and had had more experience of delivery than referents (> or = 3 times; OR = 2.5). Western style breakfast (OR = 0.5) also decreased the OR. For the multivariate analysis, past history of thyroid diseases (OR = 4.3) was positively associated with the risk of thyroid cancer and everyday coffee consumption (OR = 0.6) tended to decrease the risk. These results suggest that thyroid hormone-related factors may be involved in the risk of thyroid cancer in Japan, too. To clarify the risk involved in Japanese food, another comparative study including detailed information on iodine intake between countries and individuals is required.
影响因子：
4.1
作者：
Deluca, D;Möller, G;Adamski, J
通讯作者：
Adamski, J