The fish gill: site of action and model for toxic effects of environmental pollutants.
The fish gill: site of action and model for toxic effects of environmental pollutants.
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DOI：
10.1289/ehp.877147
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发表时间：
1987-04
影响因子：
10.4
通讯作者：
中科院分区：
文献类型：
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作者：
鳃上皮是鱼类进行气体交换、离子调节、酸碱平衡和排泄含氮废物的场所。后三个过程是由各种溶质通过上皮的被动和主动运输控制的。已发现各种环境污染物(如重金属、酸雨和有机异源物质)会影响鳃上皮的形态。与这些形态病理相关的是，我们发现血液离子水平以及鳃Na，K激活的ATPase活性和离子通量发生了变化。这种生理紊乱可能会削弱这些污染物的毒性。此外，在鱼鳃模型中受影响的上皮运输步骤类似于在人体肠道和肾脏中描述的步骤，这是各种环境毒素的作用部位。
The gill epithelium is the site of gas exchange, ionic regulation, acid-base balance, and nitrogenous waste excretion by fishes. The last three processes are controlled by passive and active transport of various solutes across the epithelium. Various environmental pollutants (e.g., heavy metals, acid rain, and organic xenobiotics) have been found to affect the morphology of the gill epithelium. Associated with these morphological pathologies, one finds alterations in blood ionic levels, as well as gill Na,K-activated ATPase activity and ionic fluxes. Such physiological disturbances may underly the toxicities of these pollutants. In addition, the epithelial transport steps which are affected in the fish gill model resemble those described in the human gut and kidney, sites of action of a variety of environmental toxins.