Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder.
Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder.
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DOI：
10.1503/jpn.110069
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发表时间：
2012-07
期刊：
影响因子：
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通讯作者：
Rebecca K. Sripada;A. King;S. Garfinkel;Xin Wang;C. Sripada;R. Welsh;I. Liberzon
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文献类型：
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作者：
Rebecca K. Sripada;A. King;S. Garfinkel;Xin Wang;C. Sripada;R. Welsh;I. Liberzon
神经影像学研究表明，创伤后应激障碍（PTSD）患者的情绪神经回路发生了改变。对这些人的情绪激活研究表明，与情绪相关的区域（包括杏仁核和杏仁核）过度激活，而情绪调节区域（包括内侧前额叶皮层（mPFC）和前扣带皮层（ACC））的激活不足。然而，很少有研究检查PTSD患者休息时的连接模式，这是一种潜在的强大方法来阐明大脑网络结构。方法：我们使用杏仁核作为种子区域，使用3T功能磁共振成像测量了患有PTSD的男性退伍军人和没有PTSD的战斗对照组的静息态脑连接。结果15名患有创伤后应激障碍的退伍军人和14名战斗对照参加了我们的研究。与对照组相比，创伤后应激障碍的退伍军人表现出更大的积极杏仁核之间的连接，减少杏仁核和海马体之间的积极连接，减少杏仁核和背侧ACC和喙侧ACC.LIMITIONS只有男性退伍军人与战斗暴露进行了测试，因此我们的研究结果不能推广到妇女或个人与非战斗相关的创伤后应激障碍。结论静息状态下的功能连接研究可以发现PTSD患者情绪回路中异常的耦合模式，提示PTSD患者情绪加工和情绪调节缺陷的可能脑机制。
BACKGROUND Converging neuroimaging research suggests altered emotion neurocircuitry in individuals with posttraumatic stress disorder (PTSD). Emotion activation studies in these individuals have shown hyperactivation in emotion-related regions, including the amygdala and insula, and hypoactivation in emotion-regulation regions, including the medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC). However, few studies have examined patterns of connectivity at rest in individuals with PTSD, a potentially powerful method for illuminating brain network structure. METHODS Using the amygdala as a seed region, we measured resting-state brain connectivity using 3 T functional magnetic resonance imaging in returning male veterans with PTSD and combat controls without PTSD. RESULTS Fifteen veterans with PTSD and 14 combat controls enrolled in our study. Compared with controls, veterans with PTSD showed greater positive connectivity between the amygdala and insula, reduced positive connectivity between the amygdala and hippocampus, and reduced anticorrelation between the amygdala and dorsal ACC and rostral ACC. LIMITATIONS Only male veterans with combat exposure were tested, thus our findings cannot be generalized to women or to individuals with non-combat related PTSD. CONCLUSION These results demonstrate that studies of functional connectivity during resting state can discern aberrant patterns of coupling within emotion circuits and suggest a possible brain basis for emotion-processing and emotion-regulation deficits in individuals with PTSD.