Spatial variation of aortic wall oxygen diffusion coefficient from transient polarographic measurements.
Spatial variation of aortic wall oxygen diffusion coefficient from transient polarographic measurements.
复制标题
瞬态极谱测量的主动脉壁氧扩散系数的空间变化。
DOI：
10.1007/bf02368610
复制
发表时间：
1992
影响因子：
3.8
通讯作者：
Goldstick,TK
中科院分区：
文献类型：
--
作者：
Buerk,DG;Goldstick,TK
Polarographic current transients following a voltage step (turn-on transient) were measured with bare cathodes (25 μm diameter) and shallowly recessed oxygen microelectrodes (<5μm diameter). Except for the initial part of the current transient, the experimental measurements were in excellent agreement with simple models in the literature, which predict an inverse relationship with. Turn-on transients were measured in aqueous solutions with known physical properties, and in aortic wall tissue from three different species (n=6 rabbits, n=3 dogs, and n=1 miniature pig). Oxygen diffusion coefficients (D) were determinedin vitroby comparing time constants measured by the same microelectrode in saline and in strips of aortic wall tissue at 37°C. On the inner side (endothelium and intima) of the aorta, D averaged (±S.E.) 7.0 (±0.8)×10−6cm2/s in 6 rabbits, 6.4 (±1.0)×10−6cm2/s in 3 dogs, and was 4.6×10−6cm2/s in the pig. On the adventitial side, D was 9.5×10−6cm2/s in 1 rabbit, 11.4 (±1.2)×10−6cm2/s in 3 dogs, and 8.1×10−6cm2/s in the pig. For every aortic strip on which D was measured from both sides, D for the inner wall was always lower, overall by a little more than one third (p<0.001). The lower D on the endothelial side may limit oxygen transport to the vascular wall and play a role in atherogenesis.
