Optical dosimetry of radiotherapy beams using Cherenkov radiation: the relationship between light emission and dose
Optical dosimetry of radiotherapy beams using Cherenkov radiation: the relationship between light emission and dose
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DOI：
10.1088/0031-9155/59/14/3789
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发表时间：
2014-07-21
影响因子：
3.5
通讯作者：
Pogue, Brian W.
中科院分区：
文献类型：
--
作者：
Glaser, Adam K.;Zhang, Rongxiao;Pogue, Brian W.
最近的研究已经提出，切伦科夫效应所发射的光可以用于许多放射治疗剂量测定应用。在某些条件下，捕获的光与预期剂量之间存在相关性，但也观察到了差异，并且尚未对理论差异进行全面检查。在这项研究中，切伦科夫发射和吸收剂量之间的基本比较，探讨了X射线光子，电子和质子使用理论和基于蒙特卡罗的分析。根据剂量与切伦科夫发射相关的发现，得出结论，对于X射线光子，光发射最适合窄束立体定向放射治疗和手术验证研究，用于验证水箱中的动态强度调制和体积调制弧形治疗计划，靠近单能源（例如，例如，在一个实施例中，Co-60和近距离治疗源），也可用于窄束和宽束的入射面和出射面成像剂量测定。对于电子的使用，切伦科夫发射被认为是只适合于表面剂量测定应用。最后，对于质子剂量测定，存在布拉格峰处的切伦科夫发射的基本缺乏，使得该技术几乎没有用处，尽管放射性同位素的光发射的照射后检测可以证明是有用的。
Recent studies have proposed that light emitted by the Cherenkov effect may be used for a number of radiation therapy dosimetry applications. There is a correlation between the captured light and expected dose under certain conditions, yet discrepancies have also been observed and a complete examination of the theoretical differences has not been done. In this study, a fundamental comparison between the Cherenkov emission and absorbed dose was explored for x-ray photons, electrons, and protons using both a theoretical and Monte Carlo-based analysis. Based on the findings of where dose correlates with Cherenkov emission, it was concluded that for x-ray photons the light emission would be optimally suited for narrow beam stereotactic radiation therapy and surgery validation studies, for verification of dynamic intensity-modulated and volumetric modulated arc therapy treatment plans in water tanks, near monoenergetic sources (e. g., Co-60 and brachy therapy sources) and also for entrance and exit surface imaging dosimetry of both narrow and broad beams. For electron use, Cherenkov emission was found to be only suitable for surface dosimetry applications. Finally, for proton dosimetry, there exists a fundamental lack of Cherenkov emission at the Bragg peak, making the technique of little use, although post-irradiation detection of light emission from radioisotopes could prove to be useful.