Circulating Ghrelin levels are decreased in human obesity
Circulating Ghrelin levels are decreased in human obesity
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DOI：
10.2337/diabetes.50.4.707
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发表时间：
2001-04-01
期刊：
影响因子：
7.7
通讯作者：
Heiman, ML
中科院分区：
文献类型：
--
作者：
Tschöp, M;Weyer, C;Heiman, ML
Ghrelin是最近从大鼠胃中分离到的一种新的生长激素促分泌素受体的内源性天然配体。Ghrelin给药刺激GH分泌，但也通过增加啮齿动物的食物摄入量和减少脂肪利用而导致体重增加。为了研究生长激素释放肽在人类肥胖发病机制中的可能参与，我们测量了身体组成，（通过双X射线吸收）以及空腹血浆ghrelin浓度（放射免疫测定）15例高加索人（8名男性和7名女性，31 +/- 9岁，92 +/- 24 kg体重和29 +/- 10%体脂，平均值为SD）和15名皮马印第安人（8名男性和7名女性，年龄33 +/- 5岁，体重97 +/- 29 kg，体脂30 +/- 8%）。血浆ghrelin与体脂百分比（r = -0.45; P = 0.01）、空腹胰岛素（r =-0.45; P = 0.01）和瘦素（r = -0.38; P = 0.03）浓度呈负相关。肥胖的加拿大人的血浆ghrelin浓度低于消瘦的白种人（P <0.01）。同样，肥胖患病率很高的皮马印第安人的空腹血浆ghrelin浓度低于白种人（87 ± 28 vs. 129 ± 34 fmol/ml; P <0.01）。空腹血浆ghrelin与身高无相关性。现在需要前瞻性的临床研究来确定ghrelin在人类肥胖发病机制中的作用。
Ghrelin is a novel endogenous natural ligand for the growth hormone (GH) secretagogue receptor that has recently been isolated from the rat stomach. Ghrelin administration stimulates GH secretion but also causes weight gain by increasing food intake and reducing fat utilization in rodents. To investigate the possible involvement of ghrelin in the pathogenesis of human obesity, we measured body composition (by dual X-ray absorption) as well as fasting plasma ghrelin concentrations (radioimmunoassay) in 15 Caucasians (8 men and 7 women, 31 +/- 9 years of age, 92 +/- 24 kg body wt, and 29 +/- 10% body fat, mean a SD) and 15 Pima Indians (8 men and 7 women, 33 +/- 5 years of age, 97 +/- 29 kg body wt, and 30 +/- 8% body fat). Pasting plasma ghrelin was negatively correlated with percent body fat (r = -0.45; P = 0,01), fasting insulin (r = - 0.45; P = 0.01) and leptin (r = -0.38; P = 0.03) concentrations. Plasma ghrelin concentration was decreased in obese Cancasians as compared with lean Caucasians (P < 0,01), Also, fasting plasma ghrelin was lower in Pima Indians, a population with a very high prevalence of obesity, compared with Caucasians (87 28 vs. 129 +/- 34 fmol/ml; P < 0,01), This result did not change after adjustment for fasting plasma insulin concentration. There was no correlation between fasting plasma ghrelin and height. Prospective clinical studies are now needed to establish the role of ghrelin in the pathogenesis of human obesity.