Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES III
Socioeconomic disparities in the seroprevalence of cytomegalovirus infection in the US population: NHANES III
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DOI：
10.1017/s0950268808000551
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发表时间：
2009-01-01
影响因子：
4.2
通讯作者：
Alley, D. E.
中科院分区：
文献类型：
--
作者：
Dowd, J. B.;Aiello, A. E.;Alley, D. E.
在美国，社会经济地位（SES）和健康结果之间有很强的关系，尽管人们对其机制知之甚少。越来越多的证据表明，终生接触传染病与随后的慢性疾病之间存在联系。暴露于感染和对感染的易感性可能是SES影响长期健康的一种方式，尽管迄今为止很少有基于人群的研究调查了美国感染的社会模式。本文测试了收入、教育、种族/民族与美国人群中不同年龄段巨细胞病毒（CMV）感染血清阳性率之间的关系，并测试了这些关系的潜在中介。该研究发现，巨细胞病毒血清患病率在早期开始并持续到中年，存在显著的种族和社会经济差异。潜在暴露不能解释SES和CMV阳性之间的关系。由于潜伏巨细胞病毒感染的再激活可能会导致生命后期的慢性疾病和免疫衰退，因此未来的研究应确定导致这些巨细胞病毒感染流行差异的暴露或易感性途径。
There is a strong relationship between socioeconomic status (SES) and health outcomes in the United States, although the mechanisms are poorly understood. Increasing evidence points to links between lifelong exposure to infectious disease and subsequent chronic disease. Exposure and susceptibility to infections may be one way SES affects long-term health, although little population-based research to date has examined social patterning of infections in the United States. This paper tests the relationship between income, education, race/ethnicity and seroprevalence of cytomegalovirus (CMV) infection at different ages in a representative sample of the US population, and tests potential mediators for these relationships. The study finds significant racial and socioeconomic disparities in CMV seroprevalence beginning at early ages and persisting into middle age. Potential exposures do not explain the relationship between SES and CMV positivity. Because reactivation of latent CMV infections may contribute to chronic disease and immune decline later in life, future research should determine the exposure or susceptibility pathways responsible for these disparities in the prevalence of CMV infection.