Neighborhood Deprivation and Risk of Age-Related Eye Diseases: A Follow-up Study in Sweden
Neighborhood Deprivation and Risk of Age-Related Eye Diseases: A Follow-up Study in Sweden
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DOI：
10.3109/09286586.2015.1056537
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发表时间：
2015-09-03
影响因子：
1.8
通讯作者：
Sundquist, Kristina
中科院分区：
文献类型：
--
作者：
Hamano, Tsuyoshi;Li, Xinjun;Sundquist, Kristina
目的：研究社区剥夺与年龄相关眼病，特别是黄斑变性、白内障、糖尿病相关眼部并发症和青光眼之间的关系。方法：研究人群包括居住在瑞典的2,060,887名男性和2,250,851名女性，年龄在40岁或以上，从2000年1月1日到研究期间首次住院/门诊登记为止，研究期间死亡、移民或研究期间结束。结果：在男性中，在调整了潜在的混杂因素(黄斑变性，OR 1.08，95%可信区间[CI]1.03~1.12；白内障，OR 1.31，95%CI 1.26~1.35；糖尿病相关眼部并发症，OR 1.36，95%CI 1.30~1.43；青光眼，OR 1.11，95%可信区间1.06~1.15)。在女性中，观察到相似的模式(黄斑变性，OR 1.11，95%CI 1.07~1.15；白内障，OR 1.36，95%CI 1.31~1.40；糖尿病相关眼部并发症，OR 1.50，95%CI 1.42~1.59；青光眼，OR 1.12，95%CI 1.08~1.17)。这些结果暗示，个人和邻里层面的因素对于预防与年龄相关的眼病很重要。
Purpose: To examine whether there is an association between neighborhood deprivation and age-related eye diseases, particularly macular degeneration, cataract, diabetes-related eye complications, and glaucoma.Methods: The study population comprised a nationwide sample of 2,060,887 men and 2,250,851 women aged 40 years or older living in Sweden who were followed from 1 January 2000 until the first hospitalization/outpatient registration for age-related eye disease during the study period, death, emigration, or the end of the study period on 31 December 2010. Multilevel logistic regression was used to estimate the association between neighborhood deprivation and age-related eye diseases.Results: In men, the odds ratio (OR) for age-related eye diseases for those living in high-deprivation neighborhoods compared to those living in low-deprivation neighborhoods remained significant after adjustment for potential confounding factors (macular degeneration, OR 1.08, 95% confidence interval [CI] 1.03-1.12; cataract, OR 1.31, 95% CI 1.26-1.35; diabetes-related eye complications, OR 1.36, 95% CI 1.30-1.43; glaucoma, OR 1.11, 95% CI 1.06-1.15). In women, similar patterns were observed (macular degeneration, OR 1.11, 95% CI 1.07-1.15; cataract, OR 1.36, 95% CI 1.31-1.40; diabetes-related eye complications, OR 1.50, 95% CI 1.42-1.59; glaucoma, OR 1.12, 95% CI 1.08-1.17).Conclusion: Our results suggest that neighborhood deprivation is associated with age-related eye diseases in both men and women. These results implicate that individual- as well as neighborhood-level factors are important for preventing age-related eye diseases.