JAPANESE PATIENTS WITH CHRONIC FATIGUE SYNDROME ARE NEGATIVE FOR KNOWN RETROVIRUS INFECTIONS
JAPANESE PATIENTS WITH CHRONIC FATIGUE SYNDROME ARE NEGATIVE FOR KNOWN RETROVIRUS INFECTIONS
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DOI：
10.1111/j.1348-0421.1993.tb01705.x
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发表时间：
1993-01-01
影响因子：
2.6
通讯作者：
YAMAZAKI, S
中科院分区：
文献类型：
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作者：
HONDA, M;KITAMURA, K;YAMAZAKI, S
尽管慢性疲劳综合症(CFS)被认为是一种以急性流感样疾病为开始的综合征，可能是由于接触了感染剂，但关于病因还没有令人信服的证据。最近，通过HTLV蛋白印迹分析和聚合酶链式反应，发现人T淋巴样病毒(HTLV-II)样病毒与CFS相关。然而，一些研究人员无法通过间接免疫荧光分析检测到HTLV-II。最近，日本有报道称有CFS患者。检测30例慢性疲劳综合征患者血清HTLV-II、HTLV-I和HIV抗体均为阴性。此外，HTLV-II的PCR分析为阴性，与患者PBMC共培养法未检测到逆转录病毒。因此，已知的人类逆转录病毒感染在日本不会导致CFS。
Although chronic fatigue syndrome (CFS) is known to be the syndrome that begins with an acute flu-like illness that may be due to the exposure to an infectious agent, there has been no convincing evidence on the causative agents. Recently, human T-lymphotropic virus type II (HTLV-II)like virus has been reported to be associated with the CFS by using HTLV Western blot analysis and polymerase chain reaction. However, some investigators could not detect HTLV-II by indirect immunofluorescence analysis. Lately, CFS patients have been reported in Japan. We detected all 30 tested patients with CFS were seronegative for HTLV-II, HTLV-I and HIV by specific peptide ELISA and Western blot. Further, PCR analysis was negative for HTLV-II and retrovirus was not detected by coculture method with patients' PBMC. Thus, known human retrovirus infections do not cause a CFS in Japan.