Increased risk of adverse pregnancy outcomes in women with rheumatoid arthritis: a nationwide population-based study
Increased risk of adverse pregnancy outcomes in women with rheumatoid arthritis: a nationwide population-based study
复制标题
DOI：
10.1136/ard.2008.105262
复制
发表时间：
2010-04-01
影响因子：
27.4
通讯作者：
Chen, Yi-Hua
中科院分区：
文献类型：
--
作者：
Lin, Herng-Ching;Chen, Shu-Fen;Chen, Yi-Hua
目的利用2001 ~ 2003年全国性人群数据库，探讨类风湿性关节炎（RA）与不良妊娠结局的关系。共纳入1912例RA母亲和9560例匹配的对照母亲。采用条件Logistic回归分析探讨低出生体重、早产、小于胎龄儿、子痫前期和分娩方式的危险性结果回归分析显示，LBW，SGA婴儿，子痫前期和CS在RA患者中分别为1.47（95% CI 1.22 - 1.78），1.20（95% CI 1.05 - 1.38），2.22（95% CI 1.59 - 3.11）和1.19结论RA孕妇出生低出生体重儿、SGA儿的危险性增加，先兆子痫和CS与未受影响的妇女相比。
Objective Using a 3-year nationwide population-based database (2001-3), this study aims to examine the relationship between rheumatoid arthritis ( RA) and adverse pregnancy outcomes.Methods The study used the Taiwan National Health Insurance Research Dataset and birth certificate registry. In total, 1912 mothers with RA and 9560 matched comparison mothers were included. Separate conditional logistic regression analyses were carried out to explore the risk of low birthweight (LBW), preterm births, small for gestational age (SGA) infants, preeclampsia and delivery mode (vaginal vs caesarean section (CS)) for the study and comparison groups.Results Regression analyses showed that the adjusted odds of LBW, SGA infants, preeclampsia and CS for women with RA were 1.47 (95% CI 1.22 to 1.78), 1.20 (95% CI 1.05 to 1.38), 2.22 (95% CI 1.59 to 3.11) and 1.19 (95% CI 1.07 to 1.31) times, respectively, that of comparison mothers.Conclusion Women with RA had an increased risk of LBW, SGA babies, preeclampsia and CS compared with unaffected women.