DOPAMINERGIC MECHANISM IN WITHDRAWAL HYPOTHERMIA IN MORPHINE-DEPENDENT RATS
DOPAMINERGIC MECHANISM IN WITHDRAWAL HYPOTHERMIA IN MORPHINE-DEPENDENT RATS
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DOI：
10.1016/0024-3205(75)90231-3
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发表时间：
1975-01-01
期刊：
影响因子：
6.1
通讯作者：
LOMAX, P
中科院分区：
文献类型：
--
作者：
COX, B;ARY, M;LOMAX, P
几种假定的神经递质在对麻醉性镇痛剂的耐受性和依赖性的形成中的作用一直是最近一项综述的主题(1)，这表明对儿茶酚胺在这种综合征中的确切作用缺乏共识。脑多巴胺在戒断攻击和戒断体温过低中的确切作用已被提出(2，3，4)，尽管在体温过低的情况下，几乎没有细节可用。因此，我们决定使用阿朴吗啡和匹莫齐特来评估多巴胺在戒断中的重要性，这两种药物声称是针对多巴胺受体的。
The role of several putative neurotransmitters in the development of tolerance and dependence to the narcotic analgesics has been the subject of a recent review (1), which demonstrated the lack of a consensus on the precise role of the catecholamines in this syndrome. A definitive role for brain dopamine in withdrawal aggression and withdrawal hypothermia has been suggested (2,3,4), although in the case of the hypothermia few details are available. We therefore decided to assess the importance of dopamine in withdrawal using apomorphine and pimozide, drugs claimed to be specific for dopamine receptors.