PSILOCIN, BUFOTENINE AND SEROTONIN - HISTORICAL AND BIOSYNTHETIC OBSERVATIONS
PSILOCIN, BUFOTENINE AND SEROTONIN - HISTORICAL AND BIOSYNTHETIC OBSERVATIONS
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DOI：
10.1080/02791072.1979.10472093
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发表时间：
1979-01-01
期刊：
影响因子：
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通讯作者：
JENSEN, RE
中科院分区：
文献类型：
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作者：
CHILTON, WS;BIGWOOD, J;JENSEN, RE
裸盖菇素、其异构体蟾蜍烯碱和神经递质5-羟色胺之间的结构关系是众所周知的。当大脑中的血清素被大量的裸盖菇素淹没时，这种结构相似性被认为与裸盖菇素作为致幻剂的作用密切相关，尽管这种机制在分子水平上还没有被详细理解。然而，值得注意的是，scrotonin具有重要的外周神经系统作用以及其在脑中的作用，并且事实上，首先从其收缩血管的作用的观察中发现和分离（早在1868年Ludwig就注意到了这种作用，Ersparmer从1930年起进行了研究）。当血凝块形成时，一种强有力的血管收缩剂从崩解的血小板进入血清，在小血管被血凝块封闭之前帮助它们止血。1930年，厄斯帕默将这种具有这些特性的难以捉摸的原理命名为”cntcrarninc”，但1948年，克利夫兰诊所的毛尔冰·拉波尔特、阿尔达·奥尔登·克雷克和欧文·佩奇将这种因素作为一种crys ta lline chem伊卡l进行研究和分离。我想我们知道这个因素的名字拉波特给它，血清素，揭示了它的来源，血清，和它的生理功能，维持血管壁的色调。在化学表征和元素分析的基础上，
The structural relationships between psilocin, its isomer bufotenine, and the neurotransmitter serotonin are well-known. Thc structural similarity is thought to be intimately involved in the action of psilocin as an hallucinogen when the brain serotonin is overwhelmed by a flood of psilocin, although this mechanism is not yet understood in detail on the molecular level. It is well to rcmcmber, however, that scrotonin has important peripheral nervous system effects as well as its effects in the brain and was, in fact, first detected and isolated fr om t hc observation of its effect in constricting the blood vessels (an effect noted by Ludwig as early as 1868 and studied by Ersparmer from 1930 on). When blood clots, a potent vasoconstrictor passes from the disintegrating platelets into the serum and helps to rcstricr bleeding from small vessels before they are closed by clots. Ersparmer named the elusive principle with these pro perties" cntcrarninc" in 1930, but the credit for pursuing and isolating this factor as a cr ys ta lline c he m ica l goes to Maur ice R apport, Ar da Alden Crecn and Irvin Page at the Cleveland Clinic in 1948. l lcnce we know this factor by the name Rapport gave it, serotonin, revealing its provenance, blood serum, and its physiological function, maintenance of the tone of the blood vessel walls. On the basis of chemical characterizat ion and elemental analysis, Rapport quickly