Neural Correlates of Reward Processing in Adolescents With a History of Inhibited Temperament
Neural Correlates of Reward Processing in Adolescents With a History of Inhibited Temperament
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DOI：
10.1111/j.1467-9280.2009.02401.x
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发表时间：
2009-08-01
影响因子：
8.2
通讯作者：
Ernst, Monique
中科院分区：
文献类型：
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作者：
Bar-Haim, Yair;Fox, Nathan A.;Ernst, Monique
功能成像数据是在一组独特的青少年（14-18 岁）执行奖励应急任务时获得的，这些青少年从婴儿期开始就进行了气质行为抑制测量。在纹状体结构（伏核、壳核、尾状核）中检查神经激活，其在促进对显着奖励相关线索的反应中发挥着已知的作用。与无行为抑制的青少年相比，有行为抑制史的青少年在相信自己选择的行为会影响奖励结果时，伏隔核的激活程度会增加。当参与者做出他们知道会带来奖励的预先指定的反应或当他们产生他们知道不会得到奖励的随机运动反应时，两组之间的神经反应没有差异。这些结果将抑制的气质和扰乱的神经反应与奖励偶然线索联系起来。
Functional imaging data were acquired during performance of a reward-contingency task in a unique cohort of adolescents (ages 14-18 years) who were characterized since infancy on measures of temperamental behavioral inhibition. Neural activation was examined in striatal structures (nucleus accumbens, putamen, caudate) with a known role in facilitating response to salient reward-related cues. Adolescents with a history of behavioral inhibition, relative to noninhibited adolescents, showed increased activation in the nucleus accumbens when they believed their selection of an action would affect reward outcome. Neural responses did not differ between the two groups when participants made a prespecified response that they knew would result in reward or when they produced random motor responses that they knew would not be rewarded. These results link inhibited temperament and perturbed neural responses to reward-contingency cues.