Xanthine dehydrogenase is transported to the Drosophila eye.
Xanthine dehydrogenase is transported to the Drosophila eye.
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DOI：
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发表时间：
1989-11
期刊：
影响因子：
3.3
通讯作者：
A. Reaume;Stephen H. Clark;A. Chovnick
中科院分区：
文献类型：
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作者：
A. Reaume;Stephen H. Clark;A. Chovnick
黑腹果蝇中的rosy（ry）基因座编码黄嘌呤脱氢酶。没有酶活性的突变体的特征在于褐色的眼睛颜色表型，反映了红眼色素的缺乏。本报告表明，在眼睛以外的某些组织中合成的酶在眼睛处被运输和隔离。先前的研究发现，没有前导序列与该分子相关，但已注意到过氧化物酶体靶向序列，并且该酶已定位于过氧化物酶体。这代表了参与中间代谢的酶从一个组织运输到另一个组织的罕见例子，也可能是过氧化物酶体蛋白从细胞分泌的第一个例子。
The rosy (ry) locus in Drosophila melanogaster codes for the enzyme xanthine dehydrogenase. Mutants that have no enzyme activity are characterized by a brownish eye color phenotype reflecting a deficiency in the red eye pigment. This report demonstrates that enzyme which is synthesized in some tissue other than the eye is transported and sequestered at the eye. Previous studies find that no leader sequence is associated with this molecule but a peroxisomal targeting sequence has been noted, and the enzyme has been localized to peroxisomes. This represents a rare example of an enzyme involved in intermediary metabolism being transported from one tissue to another and may also be the first example of a peroxisomal protein being secreted from a cell.