Disodium cromoglycate versus diet in the treatment and prevention of nickel‐positive pompholyx
Disodium cromoglycate versus diet in the treatment and prevention of nickel‐positive pompholyx
复制标题
色甘酸二钠与饮食治疗和预防镍阳性痘痘的比较
DOI：
10.1111/j.1600-0536.1990.tb01501.x
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发表时间：
1990
影响因子：
5.5
通讯作者：
G. Altomare
中科院分区：
文献类型：
--
作者：
P. Pigatto;E. Gibelli;M. Fumagalli;A. Bigardi;M. Morelli;G. Altomare
在一些被诊断为镍接触性过敏的病例中，即使在没有直接接触金属的区域，也会反复出现汗疱疹。在决定治疗方法时，应考虑可能的营养源性出汗障碍性湿疹。我们收集了24例由镍引起的出汗障碍性湿疹患者的临床数据，以评价低镍饮食与口服色甘酸二钠治疗的获益，比较客观和主观症状。低镍饮食不能改善这些患者，但从客观和主观的角度来看，接受DSCG治疗的患者的反应比对照组或饮食治疗的患者更好。接下来，我们在治疗前和治疗15天后进行了肠道通透性测试。我们发现，镍的吸收减少，同时减少通过较小的含水“孔隙”的吸收。这一现象在DSCG中最为明显。我们建议DSCG可以帮助选择性的情况下，汗疱疹。
In some cases that have been diagnosed as contact allergy to nickel, there are repeated cutaneous eruptions of pompholyx, even in areas with no direct contact with the metal. The possible alimentary origin of dyshidrotic eczema should be considered when deciding on therapy. We have collected the clinical data for 24 patients with dyshidrotic eczema caused by nickel, to evaluate the benefit of a low‐nickel diet versus treatment with oral disodium cromoglycate, comparing both objective and subjective symptoms. A low‐nickel diet does not improve these patients but those treated with DSCG reacted better, from both objective and subjective point of view, than either the controls or the patients treated by diet. We next did intestinal permeability tests before therapy and after 15 days of treatment. We found that nickel uptake diminishes simultaneously with the reduction of absorption through the smaller aqueous “pores”. This phenomenon was greatest alter DSCG. We suggest that DSCG can help selected cases of pompholyx.