Experimental validation of the nerve conduction velocity selective recording technique using a multi-contact cuff electrode
Experimental validation of the nerve conduction velocity selective recording technique using a multi-contact cuff electrode
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DOI：
10.1016/j.medengphy.2009.08.005
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发表时间：
2009-12-01
影响因子：
2.2
通讯作者：
Hennings, K.
中科院分区：
文献类型：
--
作者：
Yoshida, K.;Kurstjens, G. A. M.;Hennings, K.
蚯蚓（蚯蚓）是作为一个体外模型的周围神经只包含两个纤维，每个具有明显不同的传导速度，正中和外侧巨纤维（MGF和LGF）。蠕虫模型与多触点袖带电极一起使用，以验证不同电极触点配置的时空滤波效果以及应用延迟加法器和匹配滤波器调谐到MGF或LGF动作电位（AP）以从记录中提取传导方向和速度的效果。结果证实了电极间间距以及双极和三极记录配置对AP振幅的已知影响。它还证明了一个交叉点，其中三极记录的振幅大于单极记录，这是蠕虫中较慢的动作电位传导速度的影响。延迟加法器被认为是一种有效的速度敏感滤波器，能够根据传导速度区分单位。匹配滤波器是一种有效的手段，以消除伪影和提高信噪比，但没有发现改善选择性。(C)2009 IPEM由爱思唯尔有限公司出版。保留所有权利。
The earthworm (Lumbricus terrestris) is presented as an in vitro model of a peripheral nerve containing only two fibers each with distinctly different conduction velocities, the median and lateral giant fibers (MGF and LGF). The worm model is used with a multi-contact cuff electrode to validate the spatial-temporal filtering effect of different electrode contact configurations and the effect of applying a delay adder and matched filter tuned to either the MGF or LGF action potential (AP) to extract conduction direction and velocity from the recording. The results confirmed the known effect of inter-electrode spacing and bipolar and tripolar recording configuration on the AP amplitude. It also demonstrates a crossover point where the amplitude of the tripolar recording is larger than the monopolar recording, an effect of the slower action potential conduction velocities in the worm. The delay adder was found to be an effective velocity sensitive filter, able to discriminate units based on conduction velocity. The matched filter to be an effective means to eliminate artifact and increase signal to noise ratios, however was not found to improve selectivity. (C) 2009 IPEM Published by Elsevier Ltd. All rights reserved.