Racial variation in lipoprotein-associated phospholipase A2 in older adults
Racial variation in lipoprotein-associated phospholipase A2 in older adults
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DOI：
10.1186/1471-2261-11-38
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发表时间：
2011-06-29
影响因子：
2.1
通讯作者：
Iribarren, Carlos
中科院分区：
文献类型：
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作者：
Lee, Keane K.;Fortmann, Stephen P.;Iribarren, Carlos
背景：脂蛋白相关磷脂酶A(2)(Lp-PLA(2))是心血管事件的预测因子，已被证明随种族而不同。本研究的目的是检测与这种种族差异相关的因素。方法：我们测量了714名没有临床冠心病和没有服用血脂异常药物的健康老年人的Lp-pla(2)质量和活性。在调整了各种协变量后，我们使用多变量线性回归评估了RACE与Lp-pla(2)质量和活动水平之间的关联。这些协变量包括年龄、性别、糖尿病、高血压、体重指数、血脂测量、C反应蛋白、吸烟状况、体力活动、饮食、收入和教育水平。我们进一步检查了包括三个单核苷酸多态的遗传协变量，这些单核苷酸多态被证明与Lp-PLA2活性水平相关。结果：平均年龄为66岁。白人的脂蛋白-解放军(2)质量和活动水平最高，其次是西班牙裔和亚洲人，然后是非裔美国人；在年龄和性别调整分析中，与白人相比，每个非白人种族的这些差异都很显著(p<；0.0001)。例如，与白人相比，非洲裔美国人的Lp-PLA2质量和活性预计都比白人低55.0ngL/ml2和24.7nmoL/mlmin，这与年龄和性别无关(p<；0.0001)。调整所有协变量后，种族与Lp-pla(2)质量和活性水平(p<；0.001)显著相关，非洲裔美国人的Lp-pla(2)质量和活性低于白人(p<；0.0001)。结论：生物、生活方式、人口和特定遗传因素似乎不能解释白人和非白人之间Lp-pla(2)质量和活动水平的差异，这表明可能需要对不同种族的Lp-pla(2)质量和活动水平进行不同的解释。
Background: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a predictor of cardiovascular events that has been shown to vary with race. The objective of this study was to examine factors associated with this racial variation.Methods: We measured Lp-PLA(2) mass and activity in 714 healthy older adults with no clinical coronary heart disease and not taking dyslipidemia medication. We evaluated the association between race and Lp-PLA(2) mass and activity levels after adjustment for various covariates using multivariable linear regression. These covariates included age, sex, diabetes, hypertension, body mass index, lipid measurements, C-reactive protein, smoking status, physical activity, diet, income, and education level. We further examined genetic covariates that included three single nucleotide polymorphisms shown to be associated with Lp-PLA(2) activity levels.Results: The mean age was 66 years. Whites had the highest Lp-PLA(2) mass and activity levels, followed by Hispanics and Asians, and then African-Americans; in age and sex adjusted analyses, these differences were significant for each non-White race as compared to Whites (p < 0.0001). For example, African-Americans were predicted to have a 55.0 ng/ml lower Lp-PLA(2) mass and 24.7 nmol/ml-min lower activity, compared with Whites, independent of age and sex (p < 0.0001). After adjustment for all covariates, race remained significantly correlated with Lp-PLA(2) mass and activity levels (p < 0.001) with African-Americans having 44.8 ng/ml lower Lp-PLA(2) mass and 17.3 nmol/ml-min lower activity compared with Whites (p < 0.0001).Conclusion: Biological, lifestyle, demographic, and select genetic factors do not appear to explain variations in Lp-PLA(2) mass and activity levels between Whites and non-Whites, suggesting that Lp-PLA(2) mass and activity levels may need to be interpreted differently for various races.