Is sleep-disordered breathing an independent risk factor for hypertension in the general population (13,057 subjects)?
Is sleep-disordered breathing an independent risk factor for hypertension in the general population (13,057 subjects)?
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DOI：
10.1016/s0022-3999(00)00142-2
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发表时间：
2000-06-01
影响因子：
4.7
通讯作者：
Smirne, S
中科院分区：
文献类型：
--
作者：
Ohayon, MM;Guilleminault, C;Smirne, S
目的：睡眠呼吸障碍被认为与高血压有密切的关系，但以前的研究报告了混合的结果。这是一个重要的健康问题，需要进一步澄清，因为它对预防和控制高血压有潜在影响。研究方法：高血压和三种形式的睡眠呼吸障碍（慢性打鼾，呼吸暂停和阻塞性睡眠呼吸暂停综合征（OSAS））之间的关系进行了评估，使用英国，德国和意大利（1.59亿居民）的非制度化人口的代表性样本。这些样本由13，057名年龄在15 - 100岁之间的人组成，他们使用Sleep-EVAL系统通过电话采访了他们的睡眠习惯和睡眠症状。结果如下：OSAS在英国样本中的发生率为1.9%（95% CI：1.2%至2.3%），在德国样本中的发生率为1.8%（95% CI：1.4%至2.2%），在意大利样本中的发生率为1.1%（95% CI：0.8%至1.4%）。在控制了年龄、性别、肥胖、吸烟、饮酒、生活压力、心脏和肾脏疾病等可能的混杂效应后，OSAS是高血压的独立危险因素（比值比（OR）：9.7）。结论：来自西欧人口最多的三个国家的结果表明，OSAS是高血压的独立危险因素。睡眠时打鼾和呼吸暂停似乎是非显著的预测因素。(C)2000 Elsevier Science Inc. All rights reserved.
Objective: Sleep-disordered breathing has been hypothesized to have a close relationship with hypertension but previous studies have reported mixed results. This is an important health issue that requires further clarification because of the potential impact on the prevention and control of hypertension. Methods: The relationship between hypertension and three forms of sleep-disordered breathing (chronic snoring, breathing pauses and obstructive sleep apnea syndrome (OSAS)) was assessed using representative samples of the non-institutionalized population of the UK, Germany and Italy (159 million inhabitants). The samples were comprised of 13,057 individuals aged 15-100 years who were interviewed about their sleeping habits and their sleep symptoms over the telephone using the Sleep-EVAL system. Results: OSAS was found in 1.9% (95% CI: 1.2% to 2.3%) of the UK sample, 1.8% (95% CI: 1.4% to 2.2%) of the German sample and 1.1% (95% CI: 0.8% to 1.4%) of the Italian sample. OSAS was an independent risk factor (odds ratio (OR): 9.7) for hypertension after controlling for possible confounding effects of age, gender, obesity, smoking, alcohol consumption, life stress, and, heart and renal disease. Conclusions: Results from three of the most populated countries in Western Europe indicate that OSAS is an independent risk factor for hypertension. Snoring and breathing pauses during sleep appeared to be non-significant predictive factors. (C) 2000 Elsevier Science Inc. All rights reserved.