Palladium-Catalyzed Intramolecular C(sp2)-H Amidination by Isonitrile Insertion Provides Direct Access to 4-Aminoquinazolines from N-Arylamidines
Palladium-Catalyzed Intramolecular C(sp2)-H Amidination by Isonitrile Insertion Provides Direct Access to 4-Aminoquinazolines from N-Arylamidines
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DOI：
10.1021/ol201807n
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发表时间：
2011-09-02
期刊：
影响因子：
5.2
通讯作者：
Zhu, Qiang
中科院分区：
文献类型：
--
作者：
Wang, Yong;Wang, Honggen;Zhu, Qiang
以N-芳基脒和异腈为原料，通过钯催化的分子内芳基C-H脒化反应，合成了4-氨基-2-芳基（烷基）喹唑啉。
An efficient method for the synthesis of 4-amino-2-aryl(alkyl)quinazolines from readily available N-arylamidines and isonitriles via palladium-catalyzed intramolecular aryl C-H amidination by isonitrile insertion has been developed.