Trends in the prevalence of cerebral palsy in children born between 1988 and 2007 in Okinawa, Japan
Trends in the prevalence of cerebral palsy in children born between 1988 and 2007 in Okinawa, Japan
复制标题
DOI：
10.1016/j.braindev.2016.03.007
复制
发表时间：
2016-10-01
影响因子：
1.7
通讯作者：
Kobayashi, Yasuki
中科院分区：
文献类型：
--
作者：
Touyama, Mayumi;Touyama, Jun;Kobayashi, Yasuki
目的：本研究旨在描述1988年至2007年出生的儿童在冲绳，Japan.Method的CP患病率的趋势：本研究进行了两个时间段，第一阶段（1988年至1997年）和第二阶段（1998年至2007年），使用当地CP登记系统的数据。我们评估了脑瘫孕龄和出生体重的具体趋势的患病率和分析这些泊松回归analysis.Results：整体粗CP患病率为1.88每1000活产。约70%的CP患儿为早产或低出生体重儿（LBW），总体CP患病率在I期显著升高，II期显著降低（P < 0.05）。此外，出生体重在1000和1999 g之间的儿童的CP患病率在第一阶段增加，在第二阶段显著降低（P < 0.05）。1995 ~ 2007年出生的胎龄在28 ~ 31周的儿童中，CP患病率明显下降（P <0. 01）。结论：1998 ~ 2007年CP患病率呈下降趋势，尤其是低出生体重儿和早产儿。低出生体重儿和早产儿的高CP比例是日本冲绳人群的独特特征。(C)2016日本儿童神经病学学会。Elsevier B. V.出版，保留所有权利。
Aim: This study aimed to describe trends in CP prevalence among children born between 1988 and 2007 in Okinawa, Japan.Method: This study was conducted during two time periods, Period I (from 1988 to 1997) and Period II (from 1998 to 2007), using data from the local CP registration system. We assessed cerebral palsy gestational age and birth weight specific trends in prevalence and analyzed these with Poisson regression analysis.Results: Overall crude CP prevalence was 1.88 per 1000 live births. Approximately 70% of children with CP were born preterm or with low birth weight (LBW).Overall CP prevalence increased in Period I and decreased significantly in Period II (P < 0.05). Additionally, CP prevalence among children born with a birth weight between 1000 and 1999 g increased in Period I and decreased significantly in Period II (P < 0.05). A significant decrease was found among the children born between 1995 and 2007 with a gestational age between 28 and 31 weeks (P < 0.01).Conclusions: There was a decrease in CP prevalence from 1998 to 2007, especially among LBW children and preterm infants. The high CP proportions among LBW and preterm infants are unique features of the population of Okinawa, Japan. (C) 2016 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.