INFLUENZA A PRIME - A CLINICAL STUDY OF AN EPIDEMIC CAUSED BY A NEW STRAIN OF VIRUS
INFLUENZA A PRIME - A CLINICAL STUDY OF AN EPIDEMIC CAUSED BY A NEW STRAIN OF VIRUS
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DOI：
10.7326/0003-4819-33-2-371
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发表时间：
1950-01-01
影响因子：
39.2
通讯作者：
LOGE, JP
中科院分区：
文献类型：
--
作者：
KILBOURNE, ED;LOGE, JP
1947年2月，一种新的A型流感病毒抗原变异体感染了一个军事设施的士兵，在这场流行病中，对367名住院病人进行了全面的临床和细菌学研究。在定义疾病的病理学时，使用了流行高峰期收治的76例患者的数据。新病毒（甲型流感初型）感染产生了一种急性、良性、发热性疾病，突然发作，以中度虚脱、头痛、肌痛、鼻炎和干咳为特征，因此与先前描述的流感没有实质性区别。特别令人感兴趣的是，在流感流行高峰之后，观察到β溶血性链球菌携带者的立即增加，在接下来的一个月里，链球菌性咽炎的流行达到顶峰。
A comprehensive clinical and bacteriological study was made of 367 patients admitted during an epidemic caused by a new antigenic variant of influenza A virus which infected soldiers of an army installation in Feb. 1947. In defining the symptomatology of the disease, data from 76 patients admitted during the epidemic peak were used. Infection with the new virus (influenza A prime) produced an acute, benign, febrile disease of abrupt onset characterized by moderate prostration, headache, myalgia, coryza, and dry cough, thus not differing materially from previously described influenza. Of special interest was the immediate increase in carriers of beta hemolytic streptococci observed subsequent to the peak of the influenza epidemic, culminating in a frank epidemic of streptococcal pharyngitis the following month.