The Impact of the Glycoprotein Ia Collagen Receptor Subunit A1648G Gene Polymorphism on Coronary Artery Disease and Acute Myocardial Infarction
The Impact of the Glycoprotein Ia Collagen Receptor Subunit A1648G Gene Polymorphism on Coronary Artery Disease and Acute Myocardial Infarction
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糖蛋白Ia胶原受体亚基A1648G基因多态性对冠心病及急性心肌梗死的影响
DOI：
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发表时间：
2000
影响因子：
6.7
通讯作者：
S. Santoso
中科院分区：
文献类型：
--
作者：
H. Kroll;A. Gardemann;Andreas Fechter;W. Haberbosch;S. Santoso
血小板糖蛋白（GP）Ia是胶原的主要受体，在血小板粘附和聚集中起重要作用。不同的基因多态性已被确定，诱导不同的表达水平（C807 T）或改变的三级结构（A1648 G）的GPIa。以前，我们可以证明GPIa C807 T二态性与非致命性心肌梗死的关联。我们现在已经分析了GPIa A1648 G（Br，HPA-5）二型性对冠状动脉疾病（CAD）和急性心肌梗死（AMI）风险的影响。通过聚合酶链反应和限制性片段长度分析对2163例接受冠状动脉造影术的男性白人患者的DNA样本进行基因分型。多元回归分析校正冠心病危险因素后，确定GPIa A1648 G多态性与冠心病程度的关系。采用多元logistic回归分析计算冠心病和AMI相对危险度的比值比（OR）和双尾p值。在整个研究样本中，未检测到A1648 G二态性与CAD或AMI之间的关联。然而，在分析低风险患者亚组时，我们发现GPIa A1648 G多态性与CAD的风险和程度相关（高apoAI/apoB比值患者：OR 0.59，p = 0.0090;非吸烟者和既往吸烟者：OR 0.66，p = 0.0131;两个入选标准：OR 0.44，p = 0.0003）。对照组中A1648等位基因的相对频率较高，而CAD患者中GG 1648基因型的相对频率较高。当分析具有低表达水平的GPIa（C807纯合子）的个体时，也可检测到这种关联（具有高apoAI/apoB比率的患者：OR 0.44，p = 0.0045;非吸烟者和戒烟者：OR 0.61，p = 0.0370）。我们的研究结果表明，血小板胶原受体的A1648 G多态性在明确定义的患者群体中的CAD中起作用。
Summary Platelet glycoprotein (GP) Ia is the major receptor for collagen and plays an important role in platelet adhesion and aggregation. Different gene polymorphisms have been identified that induce either various expression levels (C807T) or alterations of the tertiary structure (A1648G) of GPIa. Previously, we could demonstrate an association of the GPIa C807T dimorphism with nonfatal myocardial infarction. We have now analysed the influence of the GPIa A1648G (Br, HPA-5) dimorphism on the risk of coronary artery disease (CAD) and acute myocardial infarction (AMI). DNA samples from 2163 male Caucasian patients who underwent coronary angiography were genotyped by polymerase chain reaction and restriction fragment length analysis. The relation of the GPIa A1648G dimorphism to the extent of CAD was determined by multiple regression analysis with adjustment for coronary risk factors. Odds ratios (OR) as an estimate of relative risk of CAD and AMI and two-tailed p-values were calculated by multiple logistic regression. In the total study sample, no association was detected between the A1648G dimorphism and CAD or AMI. However, upon analysis of low-risk patient subgroups we found an association of the GPIa A1648G polymorphism with the risk and the extent of CAD (patients with high apoAI/apoB ratio: OR 0.59, p = 0.0090; nonand ex-smokers: OR 0.66, p = 0.0131; both inclusion criteria: OR 0.44, p = 0.0003). The relative frequency of the A1648 allele was higher in controls whereas the GG1648 genotype was overrepresented in patients with CAD. This association was also detectable when individuals with low expression levels of GPIa (C807 homozygotes) were analysed (patients with high apoAI/apoB ratio: OR 0.44, p = 0.0045; nonand ex-smokers: OR 0.61, p = 0.0370). Our findings indicate that the A1648G polymorphism of the platelet collagen receptor plays a role in CAD in well defined patient groups.
影响因子：
158.5
作者：
Weiss, EJ;Bray, PF;GoldschmidtClermont, PJ
通讯作者：
GoldschmidtClermont, PJ