The Human Proteome Organization Plasma Proteome Project pilot phase: Reference specimens, technology platform comparisons, and standardized data submissions and analyses
The Human Proteome Organization Plasma Proteome Project pilot phase: Reference specimens, technology platform comparisons, and standardized data submissions and analyses
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DOI：
10.1002/pmic.200300686
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发表时间：
2004-05-01
期刊：
影响因子：
3.4
通讯作者：
Omenn, GS
中科院分区：
文献类型：
--
作者：
Omenn, GS
对健康和疾病中的循环蛋白质进行全面、系统的表征将极大地促进用于预防、诊断和治疗癌症和其他疾病的生物标志物的开发。人类蛋白质组组织血浆蛋白质组计划试点阶段的目标是：（1）比较许多技术平台的优势和局限性;（2）对比人血浆（乙二胺四乙酸、肝素、枸橼酸抗凝）和血清的参考标本，在确定的蛋白质数量和各种技术平台的干扰方面;（3）创建全球知识库/数据库。
A comprehensive, systematic characterization of cirolating proteins in health and disease will greatly facilitate development of biomarkers for prevention, diagnosis, and therapy of cancers and other diseases. The Human Proteome Organization Plasma Proteome Project pilot phase aims to (1) compare the advantages and limitations of many technology platforms; (2) contrast reference specimens of human plasma (ethylenediaminetetra acetic acid, heparin, citrate-anticoagulated) and serum, in terms of numbers of proteins identified and any interferences with various technology platforms; and (3) create a global knowledge base/data repository.