Advanced research technology for discovery of new effective compounds from Chinese herbal medicine and their molecular targets
Advanced research technology for discovery of new effective compounds from Chinese herbal medicine and their molecular targets
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DOI：
10.1016/j.phrs.2016.07.022
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发表时间：
2016-09-01
影响因子：
9.3
通讯作者：
Leung, Elaine Lai-Han
中科院分区：
文献类型：
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作者：
Wong, Vincent Kam-Wai;Law, Betty Yuen-Kwan;Leung, Elaine Lai-Han
传统的生物技术早已被人类文明广泛应用于日常生活的各个方面，如葡萄酒和醋的生产，它可以利用微生物从天然产物中产生新的植物化学物质。随着生物技术的发展，中草药在增加植物化学成分的多样性和多样性方面具有广泛的应用和优势，同时也有助于阐明中草药的治疗机制和加速新药物的开发。促进植物化学生物技术和微生物生物技术的应用，以增强植物化学多样性。细胞标记成像技术和组学技术已被用于阐明CHM的治疗机制。化学信息学和生物信息学等计算方法的应用为中药直接靶点的研究提供了新的思路。综上所述，这些技术在增加植物化学多样性、匹配分子靶点、阐明治疗机制等方面为克服中药的瓶颈提供了有效途径。潜在地，新的定向草药植物化学物质及其相应的药物靶点可以被确定。展望未来，多学科生物技术与计算技术的紧密结合，将成为中医药乃至世界制药行业加速新领域形成、发展和革命的基石。(C) 2016 Elsevier Ltd.版权所有。
Traditional biotechnology has been utilized by human civilization for long in wide aspects of our daily life, such as wine and vinegar production, which can generate new phytochemicals from natural products using micro-organism. Today, with advanced biotechnology, diverse applications and advantages have been exhibited not only in bringing benefits to increase the diversity and composition of herbal phytochemicals, but also helping to elucidate the treatment mechanism and accelerate new drug discovery from Chinese herbal medicine (CHM). Applications on phytochemical biotechnologies and microbial biotechnologies have been promoted to enhance phytochemical diversity. Cell labeling and imaging technology and omics technology have been utilized to elucidate CHM treatment mechanism. Application of computational methods, such as chemoinformatics and bioinformatics provide new insights on direct target of CHM. Overall, these technologies provide efficient ways to overcome the bottleneck of CHM, such as helping to increase the phytochemical diversity, match their molecular targets and elucidate the treatment mechanism. Potentially, new oriented herbal phytochemicals and their corresponding drug targets can be identified. In perspective, tighter integration of multi-disciplinary biotechnology and computational technology will be the cornerstone to accelerate new arena formation, advancement and revolution in the fields of CHM and world pharmaceutical industry. (C) 2016 Elsevier Ltd. All rights reserved.