Comparison of the Additive Effects of Nipradilol and Carteolol to Latanoprost in Open-Angle Glaucoma
Comparison of the Additive Effects of Nipradilol and Carteolol to Latanoprost in Open-Angle Glaucoma
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尼普地洛、卡替洛尔与拉坦前列素治疗开角型青光眼相加效果比较
DOI：
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发表时间：
2005
影响因子：
2.4
通讯作者：
Y. Ohno
中科院分区：
文献类型：
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作者：
Mai Haneda;S. Shirato;Katsuhiko Maruyama;Y. Ohno
目的比较拉坦前列素联合尼普拉地洛和卡替洛尔对青光眼患者眼压的影响。方法对50例原发性开角型青光眼患者用拉坦前列素0.005%每日1次治疗3个月。然后他们被随机分配到两组中的一组。除拉坦前列素外，一组接受0.25%尼普拉洛每日两次（尼普拉洛前组; n = 25），另一组接受2%盐酸卡替洛尔每日两次（卡替洛尔前组; n = 25），持续3个月。然后，尼普拉洛和卡替洛尔互换，受试者再接受3个月治疗。结果拉坦前列素治疗前组眼压为21.4 ± 2.3mmHg，治疗后眼压为16.8 ± 1.9mmHg（P < 0.01）;加入尼普拉洛后，IOP降至15.8 ± 1.7 mmHg，加入卡替洛尔后，IOP降至15.3 ± 2.0 mmHg。卡替洛尔预处理组基线时眼压为21.2 ± 2.0 mmHg，拉坦前列素单药治疗结束时为17.0 ± 2.1 mmHg（P < 0.01）。加入卡替洛尔后，IOP降至15.4 ± 1.8 mmHg，加入尼帕地洛后，IOP降至16.3 ± 1.9 mmHg。额外的眼压降低与卡替洛尔比与尼普拉洛更大（交叉方差分析; P = 0.0005）。结论尼普拉洛和卡替洛尔与拉坦前列素联合使用时具有累加效应。然而，卡替洛尔可能比尼普拉洛具有更有效的作用。Jpn J Ophthalmol 2006;50：33-37 ©日本眼科学会2006
PurposeTo compare the effects of nipradilol and carteolol on intraocular pressure (IOP) when added to latanoprost treatment for glaucoma patients.MethodsFifty patients with primary open-angle glaucoma were treated with latanoprost 0.005% once daily for 3 months. Then they were assigned to one of two groups randomly. One group received nipradilol 0.25% twice daily (nipradilol preceding group; n = 25), and the other carteolol hydrochloride 2% twice daily (carteolol preceding group; n = 25), for 3 months in addition to latanoprost. Then, nipradilol and carteolol were switched, and the subjects were treated for 3 more months. One eye was selected randomly for analysis.ResultsIn the nipradilol preceding group, IOP was 21.4 ± 2.3 mmHg (mean ± SD) at baseline, and 16.8 ± 1.9 mmHg at the end of latanoprost monotherapy (P < 0.01). The addition of nipradilol decreased IOP to 15.8 ± 1.7 mmHg, and the change to carteolol, to 15.3 ± 2.0 mmHg. In the carteolol preceding group, IOP was 21.2 ± 2.0 mmHg at baseline, and 17.0 ± 2.1 mmHg at the end of latanoprost monotherapy (P < 0.01). The addition of carteolol decreased IOP to 15.4 ± 1.8 mmHg, and the change to nipradilol, to 16.3 ± 1.9 mmHg. Additional IOP reduction was greater with carteolol than with nipradilol (cross-over analysis of variance; P = 0.0005).ConclusionsBoth nipradilol and carteolol have additive effects when used in combination with latanoprost. Carteolol, however, may have a more potent effect than nipradilol. Jpn J Ophthalmol 2006;50:33–37 © Japanese Ophthalmological Society 2006