Functional abnormalities of the visual processing system in subjects with mild cognitive impairment:: An fMRI study
Functional abnormalities of the visual processing system in subjects with mild cognitive impairment:: An fMRI study
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DOI：
10.1016/j.pscychresns.2007.08.013
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发表时间：
2008-08-30
影响因子：
2.3
通讯作者：
Hampel, Harald
中科院分区：
文献类型：
--
作者：
Bokde, Arun Lawrence Warren;Lopez-Bayo, Patricia;Hampel, Harald
与健康对照组（HC）相比，轻度认知障碍（MCI）受试者患阿尔茨海默病的风险更高。感觉障碍可导致认知障碍的严重程度。我们测量了MCI和HC受试者之间视觉系统的激活变化。有16名MCI受试者患有遗忘型MCI或多领域+遗忘型MCI，HC组有19名受试者。有两个任务：（a）面部匹配和（B）位置匹配任务。使用功能性磁共振成像测量脑激活。任务表现没有差异。HC组选择性地激活腹侧和背侧通路在面对和位置匹配任务，分别，而MCI组没有。在位置匹配任务中，MCI组的左额叶比HC组有更大的激活。与MCI组相比，HC组中没有激活增加的区域。MCI组作为一种代偿机制，在位置匹配任务中激活了两条视觉通路，并增加了左额叶的激活。据我们所知，这是第一个研究MCI的视觉处理。(c)2007爱思唯尔爱尔兰有限公司保留所有权利。
Subjects with mild cognitive impairment (MCI) have a higher risk of developing Alzheimer's disease compared with healthy controls (HC). Sensory impairment can contribute to the severity of cognitive impairment. We measured the activation changes in the visual system between MCI and HC subjects. There were 16 MCI Subjects with either amnestic MCI or multiple-domain+ amnestic MCI and an HC group of 19 subjects. There were two tasks: (a) a face matching and (b) a location matching task. Brain activation was measured using functional magnetic resonance imaging. There were no differences in task performance. The HC group selectively activated the ventral and dorsal pathways during the face and location matching tasks, respectively, while the MCI group did not. The MCI group had greater activation than the HC group in the left frontal lobe during the location matching task. There were no areas of increased activation in the HC group compared with the MCI group. The MCI group, as a compensatory mechanism, activated both visual pathways and increased activation in the left frontal lobe during the location matching task compared with the healthy controls. To our knowledge, this is the first study that has examined visual processing in MCI. (c) 2007 Elsevier Ireland Ltd. All rights reserved.