Factors associated with antimicrobial-resistant Escherichia coli in zoo animals
Factors associated with antimicrobial-resistant Escherichia coli in zoo animals
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DOI：
10.1016/j.rvsc.2011.09.006
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发表时间：
2012-10-01
影响因子：
2.4
通讯作者：
Tamura, Yutaka
中科院分区：
文献类型：
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作者：
Ishihara, Kanako;Hosokawa, Yuko;Tamura, Yutaka
分析了动物园动物携带耐药性大肠杆菌分离株的相关因素。与32只未治疗动物的分离株（9.4%）相比，在选择阿莫西林作为一线治疗和11只接受抗菌剂治疗的动物对氨苄西林的耐药百分比（54.5%）显著更高之间观察到相关性。此外，11只给药动物对卡那霉素（36.4%）、庆大霉素（27.3%）、甲氧苄啶（27.3%）和四环素（63.6%）的耐药百分比显著高于32只未给药动物（分别为3.1%、3.1%、3.1%和25%），尽管这些抗菌剂很少使用。所有卡那霉素、庆大霉素和甲氧苄啶耐药分离株和半数以上来自治疗动物的四环素耐药分离株也对氨苄青霉素耐药。对其他抗菌药物与氨苄青霉素的共耐药性可能导致对很少使用的抗菌药物的耐药性增加。目前的调查揭示了抗生素治疗与动物园动物中抗生素耐药性细菌的传播之间的关联。(C)2011爱思唯尔有限公司版权所有。
Factors associated with the carriage of antimicrobial-resistant Escherichia coli isolates were analysed among zoo animals. An association was observed between selection of amoxicillin as the first-line therapy and a significantly higher percentage of resistance to ampicillin (54.5%) from 11 animals treated with antimicrobials, compared with isolates from 32 untreated animals (9.4%). In addition, the percentage resistance to kanamycin (36.4%), gentamicin (27.3%), trimethoprim (27.3%) and tetracycline (63.6%) from 11 treated animals was significantly higher than those from 32 untreated animals (3.1%, 3.1%, 3.1% and 25%, respectively), although these antimicrobials were rarely used. All kanamycin-, gentamicin- and trimethoprim-resistant isolates and more than half of the tetracycline-resistant isolates from treated animals were also resistant to ampicillin. Co-resistance to other antimicrobials with ampicillin was suggested to contribute to an increasing of resistance towards antimicrobials that were rarely administered. The present investigation revealed an association of antimicrobial treatment with the spread of antimicrobial-resistant bacteria among zoo animals. (C) 2011 Elsevier Ltd. All rights reserved.