Anti-C1q antibodies and systemic lupus erythematosus in the Tunisian population
Anti-C1q antibodies and systemic lupus erythematosus in the Tunisian population
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DOI：
10.1016/j.patbio.2013.01.007
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发表时间：
2013-06-01
影响因子：
--
通讯作者：
Sghiri, R.
中科院分区：
文献类型：
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作者：
Trad, B.;Ben Hassine, H.;Sghiri, R.
目标. - 系统性红斑狼疮（SLE）的一个重要特征是自身抗体的广泛存在。虽然非特异性，但抗补体C1q（抗C1q）与活动性肾炎的发生相关。本研究旨在调查突尼斯SLE患者抗C1q抗体的患病率及其与临床表现，特别是肾脏受累的关系。- 采用ELISA法检测98例SLE患者、55例类风湿关节炎（RA）患者和65例健康人（HI）血清中IgG抗C1q抗体。- 抗C1q在SLE、RA和HI患者中分别为53例（54.1%）、3例（5%）和6例（9.3%）。在65例肾脏受累患者中，35例（53.8%）患者存在抗C1q。抗C1q抗体与肾或肾外表现之间无显著相关性。抗C1q抗体滴度与SLEDAI指数无相关性。抗C1q与抗核小体（P = 0.001）、抗Sm（P = 0.01）和低C4水平（P = 0.046）显著相关。抗C1q和抗dsDNA抗体的同时存在与肾脏表现无关。- 我们的研究表明，抗C1q的患病率与以前报道的高加索人群。这些抗体与低C4水平相关。然而，抗C1 q与肾脏受累或肾炎严重程度之间没有相关性。(C)2013年Elsevier Masson SAS。All rights reserved.
Objectives. - The presence of a wide variety of autoantibodies is a characteristic feature of systemic lupus erythematosus (SLE). Although non-specific, anti-complement C1q (anti-C1q) were shown to correlate with the occurrence of active nephritis. The present study aimed to investigate the prevalence of anti-C1q in Tunisian SLE patients and their association with clinical manifestations, especially renal involvement.Patients and methods. - IgG anti-C1q antibodies were assessed by Elisa in 98 SLE patients, 55 patients with rheumatoid arthritis (RA) and 65 healthy individuals (HI).Results. - Anti-C1q were found in 53 (54.1%) patients with SLE, three (5%) patients with RA and six (9.3%) HI. Among the 65 patients with renal involvement, anti-C1q were present in 35 (53.8%) patients. There was no significant association between anti-C1q and renal or extrarenal manifestations. In addition, there was no correlation between anti-C1q titer and SLEDAI index. Anti-C1q were significantly associated with anti-nucleosome (P = 0.001), anti-Sm (P = 0.01) and a low C4 level (P = 0.046). Concomitant presence of anti-C1q and anti-dsDNA antibodies was not associated with renal manifestations.Conclusion. - Our study shows that prevalence of anti-C1q was comparable with that previously reported in Caucasian populations. These antibodies were associated with a low C4 level. However, there was no association between anti-C1q and renal involvement or severity of nephritis. (C) 2013 Elsevier Masson SAS. All rights reserved.