Vascular permeability in chronic rhinosinusitis enhances accumulation and retention of nanoscale pegylated liposomes.
Vascular permeability in chronic rhinosinusitis enhances accumulation and retention of nanoscale pegylated liposomes.
复制标题
慢性鼻窦炎的血管通透性增强了纳米级聚乙二醇化脂质体的积累和保留。
DOI：
10.1016/j.nano.2021.102453
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Ghandehari,Hamidreza
中科院分区：
文献类型：
--
作者：
Khurana,Nitish;Yathavan,Bhuvanesh;Jedrzkiewicz,Jolanta;Gill,AmarbirS;Pulsipher,Abigail;Alt,JeremiahA;Ghandehari,Hamidreza
慢性鼻-鼻窦炎(CRS)是一种令人衰弱的鼻腔粘膜炎性疾病，严重影响患者的生活质量。由于缺乏治疗创新，这种疾病的管理方面的进展受到了阻碍。据推测，CRS患者病变鼻窦内血管的增加可能允许通过纳米级脂质体载体改善全身给药。这样的系统可以增强药物在鼻窦内的分布、积累和滞留，最终导致改善患者的预后。合成了吲哚青绿(ICG)聚乙二醇化脂质体，并对其进行了表征，并在CRS小鼠模型上进行了系统给药。观察ICG在鼻腔组织中的蓄积和滞留情况。与健康对照组相比，CRS小鼠表现出显著的鼻腔组织蓄积和聚乙二醇化脂质体icg长达21 天的滞留(P<； 0.001)。相反，两组在24 h后体内游离ICG均被清除。
Chronic rhinosinusitis (CRS) is a debilitating inflammatory disorder of the sinonasal mucosa that substantially diminishes patient quality of life. Progress surrounding management of this disease has been crippled by a lack of therapeutic innovation. It has been posited that increased vascularity within the diseased sinuses of patients with CRS may allow for improved systemic drug delivery via nanoscale liposomal carriers. Such a system could enhance drug distribution, accumulation, and retention within the sinuses, ultimately leading to improved patient outcomes. PEGylated liposomes loaded with indocyanine green (ICG) were synthesized, characterized and systemically administered in a mouse model of CRS. Accumulation and retention of ICG in sinonasal tissue were evaluated. Compared to healthy controls, CRS mice showed significant sinonasal tissue accumulation and retention of PEGylated liposomal ICG for up to 21 days (P< 0.001). Conversely, free ICG was eliminated from the body after 24 h in both groups.