Organization of connections of the basal and accessory basal nuclei in the monkey amygdala
Organization of connections of the basal and accessory basal nuclei in the monkey amygdala
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DOI：
10.1046/j.1460-9568.2000.00082.x
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发表时间：
2000-06-01
影响因子：
3.4
通讯作者：
Bonda, E
中科院分区：
文献类型：
--
作者：
Bonda, E
用顺行示踪剂菜豆-亮氨酸凝集素(PHA-L)和生物素化葡聚糖胺(BDA)研究了猕猴基底核和副基底核的内在联系。对基底核核内联系的分析表明，基底核内有5个模块：背侧、中间、腹外侧部、腹侧内侧和杏仁核周围沟皮质。背侧部突出至中间部。在外侧，中间部投射到腹外侧部和腹内侧部的背部。腹侧支投射到腹侧内侧部和杏仁体周围沟皮质，这似乎构成了基底核向杏仁皮质表面的内侧延伸。在内侧，腹侧内侧部向中间和背侧部投射。因此，这些模块之间的联系在核内形成了功能微柱，具有不同的信息流模式，即背侧到腹侧，外侧到内侧腹侧，腹侧到背侧。对副基底核的核内联系的观察表明，它们被组织成两个相对不同的区域：背侧部投射到腹侧部，腹侧部主要投射到腹内侧部。至杏仁核其他区域的投射起源于基底核和附属基底核的特定分区，并且在地形图上是分布的。基底核的内在联系的组织与特定的杏仁皮质联系相关，并表明杏仁核内发生了广泛的信息汇聚，这可能影响颞叶、顶叶通路和海马场的活动。
The present study investigated the intrinsic connections of the basal and accessory basal nuclei of the Macaca fascicularis monkey by means of the anterograde tracers Phaseolus vulgaris-leucoagglutinin (PHA-L) and biotinylated dextran amine (BDA). Analysis of the intranuclear connections of the basal nucleus indicates that there are five modules: dorsal, intermediate, ventral lateral, ventral medial and periamygdaloid sulcal cortex. The dorsal division projects to the intermediate division. Laterally, the intermediate division projects to the ventral lateral division and dorsal parts of the ventral medial division. Ventrally, the ventral lateral division projects to the ventral medial division and periamygdaloid sulcal cortex, which appears to constitute a medial extension of the basal nucleus onto the cortical surface of the amygdala. Medially, the ventral medial division projects to the intermediate and dorsal divisions. Thus, the connections between these modules form functional microcolumns within the nucleus with distinct patterns of information flow that are dorsal to ventral laterally, lateral to medial ventrally, and ventral to dorsal medially. Observations on the intranuclear connections of the accessory basal nucleus suggest that they are organized into two relatively distinct domains: the dorsal division projects to the ventral division and the ventral division projects primarily to the ventromedial division. Projections to other amygdaloid areas originate in select divisions of the basal and accessory basal nuclei, and are topographically distributed. The organization of intrinsic connections of the basal nuclei correlates with specific amygdalo-cortical connections and suggests that extensive convergence of information takes place within the amygdala, which potentially influences activity at both the temporal and parietal pathways and hippocampal fields.