High-density lipoprotein heterogeneity and function in reverse cholesterol transport.
High-density lipoprotein heterogeneity and function in reverse cholesterol transport.
复制标题
DOI：
10.1097/mol.0b013e328338472d
复制
发表时间：
2010-06
影响因子：
4.4
通讯作者：
Phillips MC
中科院分区：
文献类型：
--
作者：
Rothblat GH;Phillips MC
HDL 是一种心脏保护性脂蛋白，至少部分是因为它能够介导胆固醇逆向转运 (RCT)。越来越清楚的是，HDL 的抗动脉粥样硬化作用不仅取决于其在循环血液中的浓度，还取决于其生物“质量”。这篇综述总结了我们目前对 HDL 颗粒各个亚类的生物活性如何影响 RCT 中 HDL 整体性能的理解。最近的研究表明，含有载脂蛋白 A-I 的新生 HDL 颗粒是异质的，并且这些颗粒对 RCT 途径发挥不同的影响。已在小鼠中详细检查了巨噬细胞的 RCT，并评估了血浆因子（卵磷脂胆固醇酰基转移酶、胆固醇酯转移蛋白、磷脂转移蛋白）和细胞因子（ATP 结合盒转运蛋白 A1、ATP 结合盒转运蛋白 G1、B 类清道夫受体 1 型）的作用。操纵这些因素对 RCT 和动脉粥样硬化具有一致的影响，但血浆 HDL 水平并不能可靠地预测 RCT 程度。此外，HDL 胆固醇或载脂蛋白 A-I 水平不一定与巨噬细胞流出胆固醇的程度相关。需要更多地了解特定 HDL 亚种的贡献。 HDL 的抗动脉粥样硬化特性由 HDL 亚种的功能决定。就 RCT 而言，胆固醇通过该途径的运动速率至关重要，并且特定类型的 HDL 颗粒对此过程的贡献正在得到更好的定义。
HDL is a cardioprotective lipoprotein, at least in part, because of its ability to mediate reverse cholesterol transport (RCT). It is becoming increasingly clear that the antiatherogenic effects of HDL are not only dependent on its concentration in circulating blood but also on its biological ‘quality’. This review summarizes our current understanding of how the biological activities of individual subclasses of HDL particles contribute to overall HDL performance in RCT. Recent work indicates that apolipoprotein A-I-containing nascent HDL particles are heterogeneous and that such particles exert different effects on the RCT pathway. RCT from macrophages has been examined in detail in mice and the roles of plasma factors (lecithin-cholesterol acyltransferase, cholesterol ester transfer protein, phospholipid transfer protein) and cell factors (ATP-binding cassette transporter A1, ATP-binding cassette transporter G1, scavenger receptor class B type 1) have been evaluated. Manipulation of such factors has consistent effects on RCT and atherosclerosis, but the level of plasma HDL does not reliably predict the degree of RCT. Furthermore, HDL cholesterol or apolipoprotein A-I levels do not necessarily correlate with the magnitude of cholesterol efflux from macrophages; more understanding of the contributions of specific HDL subspecies is required. The antiatherogenic quality of HDL is defined by the functionality of HDL subspecies. In the case of RCT, the rate of cholesterol movement through the pathway is critical and the contributions of particular types of HDL particles to this process are becoming better defined.
登录
查看更多内容
影响因子：
6.5
作者：
Duong, PT;Collins, HL;Phillips, MC
通讯作者：
Phillips, MC
影响因子：
2.9
作者：
CASTRO, GR;FIELDING, CJ
通讯作者：
FIELDING, CJ
DOI：
10.1016/j.bbalip.2005.11.012
发表时间：
2005-12-30
影响因子：
4.8
作者：
Calpe-Berdiel, L;Rotllan, N;Escolà-Gil, JC
通讯作者：
Escolà-Gil, JC
DOI：
10.1161/atvbaha.108.182303
发表时间：
2009-04-01
影响因子：
8.7
作者：
Brunham, Liam R.;Singaraja, Roshni R.;Hayden, Michael R.
通讯作者：
Hayden, Michael R.
影响因子：
4.8
作者：
Ji, Y;Jian, B;Tall, AR
通讯作者：
Tall, AR