Gabapentin suppresses spasticity in the spinal cord-injured rat
Gabapentin suppresses spasticity in the spinal cord-injured rat
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DOI：
10.1016/j.neuroscience.2007.07.020
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发表时间：
2007-11-23
期刊：
影响因子：
3.3
通讯作者：
Dwyer, M. K.
中科院分区：
文献类型：
--
作者：
Kitzman, P. H.;Uhl, T. L.;Dwyer, M. K.
痉挛对脊髓损伤（SCI）患者的生活质量造成了重大的不利影响。在我们的实验室最近的观察表明，在骶S-2水平的脊髓横断诱导的骶尾运动神经元在痉挛的时间是存在于尾部肌肉的神经传入神经元的显着增加。本研究探讨了加巴喷丁，已被证明可以减少谷氨酸释放，在管理痉挛内的尾部musculature.Method：在这个盲目的，交叉研究的成年Sprague-Dawley大鼠与S2脊髓横断的疗效进行了测试行为的痉挛在尾部肌肉组织的进展，使用我们建立的系统。当动物表现出显着水平的痉挛行为（例如对快速伸展、有害和非有害皮肤刺激的反应增加）时，它们接受盐水或抗癫痫药物加巴喷丁（GBP; 50 mg/kg i. p.）结果：与生理盐水组相比，GBP组大鼠在注射GBP后1、3 h的痉挛行为和肌电活动均显著降低（P < 0. 05）。痉挛的行为和EMG活动逐渐增加，随着时间的推移，并返回到基线活动24 h post-injection.Conclusion：加巴喷丁减少SCI引起的痉挛的行为和电生理表现，在尾部肌肉组织，在一个时间依赖性的方式。(c)2007年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Spasticity poses a major detrimental impact on the quality of life in a significant number of people with spinal cord injury (SCI). Recent observations in our laboratory suggest that spinal transection at the sacral S-2 level induces a significant increase in glutamatergic input to sacrocaudal motoneurons during the time spasticity is present in the tail muscles. The present study examined the efficacy of gabapentin, an agent that has been shown to reduce glutamate release, in managing spasticity within the tail musculature.Method: In this blinded, crossover study adult Sprague-Dawley rats with S2 spinal transections were tested behaviorally for the progression of spasticity in the tail musculature using our established system. When the animals demonstrated a significant level of spastic behavior (e.g. increased response to quick stretch, noxious and non-noxious cutaneous stimuli), they received either saline or the antiepileptic agent gabapentin (GBP; 50 mg/kg i.p.) and were assessed behaviorally and electrophysiologically at 1, 3, 6, 12 and 24 h post-injection.Results: Both spastic behavior and electromyography (EMG) activity were significantly decreased at 1 and 3 h post-GBP injection when compared with the activity level following administration of saline. Spastic behavior and EMG activity gradually increased over time and returned to baseline activity by 24 h post-injection.Conclusion: Gabapentin diminishes both the behavioral and electrophysiological manifestation of SCI-induced spasticity, in the tail musculature, in a time dependent manner. (c) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.