Clinical significance of α-catenin, collagen IV, and Ki-67 expression in epithelial ovarian cancer
Clinical significance of α-catenin, collagen IV, and Ki-67 expression in epithelial ovarian cancer
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DOI：
10.1200/jco.1998.16.8.2591
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发表时间：
1998-08-01
影响因子：
45.3
通讯作者：
Syrjanen, K
中科院分区：
文献类型：
--
作者：
Anttila, M;Kosma, VM;Syrjanen, K
目的：分析α-连环蛋白和IV型胶原在上皮性卵巢癌中的表达，特别是其预后意义以及与临床和病理特征的相关性，以及细胞增殖标记物Ki-67。患者和方法：对316例上皮性卵巢癌患者石蜡包埋标本中α-连环蛋白、IV型胶原和Ki-67的表达进行免疫组化分析。α-连环蛋白和IV型胶原蛋白的表达与国际妇产科联合会（FIGO）分期或增殖标记物Ki-67无关。在50%的原发性肿瘤中α-连环蛋白表达降低（< 100%）。α-连环蛋白和IV型胶原表达减少与高组织学分级直接相关（P <0.001）。在单变量和多变量分析中，Ki-67增殖显著预测总生存率。在86例I期肿瘤患者的亚组中，α-连环蛋白表达降低（< 100%）作为阴性预后因素接近统计学显著性（P = .035），并在多变量分析中保持其统计学显著性（P = .025）。在单变量（P = 0.0107）和多变量分析（P = 0.0105）中，与正常表达相比，α-连环蛋白的低（< 30%）表达（n = 10）是较差生存的标志。结论：α-连环蛋白表达似乎是那些可能运行不太有利的过程的FIGO I期肿瘤的有用标记。高细胞增殖活性与低存活率相关。在未来，α-连环蛋白和Ki-67的表达应该在一个大型的前瞻性队列中进行研究，该队列包括早期癌症，以选择更具有侵袭性的肿瘤进行强烈的早期化疗，J Clin Oncol 16：2591-2600。(C)1998年，美国临床肿瘤学会。
Purpose: To analyze alpha-catenin and collagen IV expression in epithelial ovarian cancer with special reference to their prognostic significance and correlations with clinical and pathologic characteristics, as well as cell proliferation marker Ki-67.Patients and Methods: alpha-Catenin, collagen IV, and Ki-67 expression was immunohistochemically analyzed in paraffin-embedded specimens of 316 patients with epithelial ovarian cancer.Results: alpha-Catenin and collagen IV expression was not interrelated or related to International Federation of Gynecology and Obstetrics (FIGO) stage or proliferation marker Ki-67. alpha-Catenin expression was reduced (< 100%) in 50% of primary tumors. Reduced alpha-catenin and collagen IV expression war directly related to high histologic grade (P < .001). In both univariate and multivariate analyses, Ki-67 proliferation significantly predicted overall survival, In the subset of 86 patients with stage I tumor a reduced (< 100%) alpha-catenin expression approached statistical significance as a negative prognostic factor (P = .035) and retained its statistical significance in the multivariate analysis (P = .025). The low (< 30%) expression of alpha-catenin (n = 10) was a sign of inferior survival as compared with normal expression in both the univariate (P = .0107) and multivariate analyses (P = .0105).Conclusion: alpha-Catenin expression seems to be a useful marker of those FIGO stage I tumors likely to run a less favorable course. The high cell proliferative activity was associated with poor survival. In the future, alpha-catenin and Ki-67 expression should be studied in a large prospective cohort that includes early-stage cancers to select the more aggressive tumors for intense early chemotherapy, J Clin Oncol 16:2591-2600. (C) 1998 by American Society of Clinical Oncology.