Diagnosing Fracture-Related Infection: Current Concepts and Recommendations
Diagnosing Fracture-Related Infection: Current Concepts and Recommendations
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DOI：
10.1097/bot.0000000000001614
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发表时间：
2020-01-01
影响因子：
2.3
通讯作者：
Metsemakers, Willem-Jan
中科院分区：
文献类型：
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作者：
Govaert, Geertje A. M.;Kuehl, Richard;Metsemakers, Willem-Jan
骨折相关感染（FRI）是骨损伤后的一种严重并发症，并可能构成严重的诊断挑战。总的来说，关于FRI的诊断标准的科学证据有限，因此，AO基金会和欧洲骨关节感染学会提出了FRI的共识定义，以规范诊断标准，提高患者护理质量和未来研究对该疾病的适用性。本文的目的是总结现有的证据，并为FRI的诊断提供建议。为此，我们将讨论FRI的共识定义，并根据与临床参数、血清炎症标志物、成像模式、组织和超声液体取样、分子生物学技术和组织病理学检查的诊断价值相关的现有证据，提出更新建议。第二，就微生物样本采样和与FRI相关的实验室操作程序提供建议。证据等级：诊断性v级。参见《作者指南》获得证据等级的完整描述。
Fracture-related infection (FRI) is a severe complication after bone injury and can pose a serious diagnostic challenge. Overall, there is a limited amount of scientific evidence regarding diagnostic criteria for FRI. For this reason, the AO Foundation and the European Bone and Joint Infection Society proposed a consensus definition for FRI to standardize the diagnostic criteria and improve the quality of patient care and applicability of future studies regarding this condition. The aim of this article was to summarize the available evidence and provide recommendations for the diagnosis of FRI. For this purpose, the FRI consensus definition will be discussed together with a proposal for an update based on the available evidence relating to the diagnostic value of clinical parameters, serum inflammatory markers, imaging modalities, tissue and sonication fluid sampling, molecular biology techniques, and histopathological examination. Second, recommendations on microbiology specimen sampling and laboratory operating procedures relevant to FRI will be provided.Level of Evidence:Diagnostic Level V. See Instructions for Authors for a complete description of levels of evidence.