Cytotoxic polyacetylenes from the marine sponge Petrosia sp.
Cytotoxic polyacetylenes from the marine sponge Petrosia sp.
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DOI：
10.1021/np9803427
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发表时间：
1999-04-01
影响因子：
5.1
通讯作者：
Lee, H
中科院分区：
文献类型：
--
作者：
Kim, JS;Lim, YJ;Lee, H
三个C-4 - 6（1- 3）和三个C-30（4-6）聚炔醇对一小组人实体瘤细胞系的细胞毒活性已从海绵岩藻属分离。虽然化合物1被鉴定为petrocortyne A的立体异构体，化合物2-5的结构以前没有报道，并通过光谱方法建立。化合物6被鉴定为已知化合物petrosiacetylene D。化合物1-5的立体化学通过改进的Mosher方法测定。
Three C-46 (1--3) and three C-30 (4-6) polyacetylenic alcohols with cytotoxic activity against a small panel of human solid-tumor cell lines have been isolated from the marine sponge Petrosia sp. Although compound 1 was identified as the stereoisomer of petrocortyne A, the structures of compounds 2-5 have not been previously reported and were established by spectral methods. Compound 6 was identified as the known compound petrosiacetylene D. The stereochemistry of compounds 1-5 was determined by the modified Mosher's method.