Antimicrobial Susceptibilities of 1,730Haemophilus influenzae Respiratory Tract Isolates in Spain in 1998-1999
Antimicrobial Susceptibilities of 1,730Haemophilus influenzae Respiratory Tract Isolates in Spain in 1998-1999
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1998-1999年西班牙1,730株流感嗜血杆菌呼吸道分离株的抗菌药物敏感性
DOI：
10.1128/aac.45.11.3226-3228.2001
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发表时间：
2001
影响因子：
4.9
通讯作者：
C. Fernández
中科院分区：
文献类型：
--
作者：
F. Marco;J. García‐de‐Lomas;C. García;E. Bouza;L. Aguilar;C. Fernández
摘要 在 1,730 株流感嗜血杆菌分离株中发现 β-内酰胺酶患病率为 23%。氨苄青霉素敏感性为 70%，12% β-内酰胺酶阴性菌株对氨苄青霉素敏感性降低（BLNAR 表型）。对头孢克洛和克拉霉素的敏感性为 90%，而对头孢噻肟、头孢克肟、阿奇霉素和头孢呋辛的敏感性接近 100%。迄今为止，环丙沙星耐药（0.1%）和β-内酰胺酶阳性阿莫西林/克拉维酸（BLPACR）表型（0.1%）尚属传闻。
ABSTRACT A β-lactamase prevalence of 23% was found among 1,730Haemophilus influenzae isolates. Ampicillin susceptibility was 70%, and 12% of β-lactamase-negative strains presented diminished susceptibility to ampicillin (BLNAR phenotype). Susceptibility of 90% was found for cefaclor and clarithromycin, whereas it was nearly 100% for cefotaxime, cefixime, azithromycin, and cefuroxime. Ciprofloxacin-resistant (0.1%) and β-lactamase-positive amoxicillin/clavulanate-resistant (BLPACR) phenotypes (0.1%) are anecdotal so far.