Retrospective comparison of rectal toxicity between carbon-ion radiotherapy and intensity-modulated radiation therapy based on treatment plan, normal tissue complication probability model, and clinical outcomes in prostate cancer
Retrospective comparison of rectal toxicity between carbon-ion radiotherapy and intensity-modulated radiation therapy based on treatment plan, normal tissue complication probability model, and clinical outcomes in prostate cancer
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DOI：
10.1016/j.ejmp.2021.08.013
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发表时间：
2021-09-11
影响因子：
3.4
通讯作者：
Ohno, Tatsuya
中科院分区：
文献类型：
--
作者：
Fukata, Kyohei;Kawamura, Hidemasa;Ohno, Tatsuya
这项回顾性研究评估了152例前列腺癌患者的治疗计划数据和临床结局：76例连续患者接受碳离子放射治疗，76例后续患者接受中等次强度调制光子放射治疗。这两种模式进行了比较，使用线性二次模型等效剂量2戈伊每部分直肠或直肠壁剂量体积直方图，3.6戈伊每部分转换直肠剂量体积直方图，正常组织并发症的概率模型，和实际的临床结果。基于剂量-体积直方图和正常组织并发症概率模型，预测碳离子放射治疗的直肠不良事件概率低于调强光子放射治疗。在本研究中，两种模式之间直肠不良事件的临床结局无差异。
This retrospective study assessed the treatment planning data and clinical outcomes for 152 prostate cancer patients: 76 consecutive patients treated by carbon-ion radiation therapy and 76 consequtive patients treated by moderate hypo-fractionated intensity-modulated photon radiation therapy. These two modalities were compared using linear quadratic model equivalent doses in 2 Gy per fraction for rectal or rectal wall dose-volume histogram, 3.6 Gy per fraction-converted rectal dose-volume histogram, normal tissue complication probability model, and actual clinical outcomes. Carbon-ion radiation therapy was predicted to have a lower probability of rectal adverse events than intensity-modulated photon radiation therapy based on dose-volume histograms and normal tissue complication probability model. There was no difference in the clinical outcome of rectal adverse events between the two modalities compared in this study.