Presence of FoxP3+ regulatory T cells predicts outcome of subclinical rejection of renal allografts
Presence of FoxP3+ regulatory T cells predicts outcome of subclinical rejection of renal allografts
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DOI：
10.1681/asn.2007111174
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发表时间：
2008-10-01
影响因子：
13.6
通讯作者：
Grinyo, Josep M.
中科院分区：
文献类型：
--
作者：
Bestard, Oriol;Cruzado, Josep M.;Grinyo, Josep M.
同种异体肾移植亚临床排斥反应是指肾功能稳定但仍发生急性排斥反应的组织学类型。SCR的临床方法是有争议的;它将有助于确定生物标志物，可以确定是否确定细胞浸润是有害的。为了研究FoxP 3（+）调节性T细胞（Treg）的存在是否有助于确定在6个月方案活检中观察到的肾小管间质浸润的功能重要性，对37例SCR进行了评价。FoxP 3（+）Treg的存在可区分无害性浸润和有害性浸润，这可通过独立预测移植后2年和3年移植物功能更好来证明。此外，FoxP 3（+）Treg/CD 3（+）T细胞比率与移植后2年的移植物功能呈正相关，表明整体T细胞浸润中Treg比例的增加可能有助于肾移植;因此，方案活检中SCR患者的FoxP 3（+）Treg免疫染色可能最终有助于识别可能需要改变免疫抑制方案的患者。
Subclinical rejection (SCR) of renal allografts refers to histologic patterns of acute rejection despite stable renal function. The clinical approach to SCR is controversial; it would be helpful to identify biomarkers that could determine whether the identified cellular infiltrates were detrimental. For investigation of whether the presence of FoxP3(+) regulatory T cells (Treg) could help determine the functional importance of tubulointerstitial infiltrates observed in 6-mo protocol biopsies, 37 cases of SCR were evaluated. The presence of FoxP3(+) Treg discriminated harmless from injurious infiltrates, evidenced by independently predicting better graft function 2 and 3 yr after transplantation. Furthermore, the FoxP3(+) Treg/CD3(+) T cell ratio positively correlated with graft function at 2 yr after transplantation, suggesting that an increasing proportion of Treg within the global T cell infiltrate may facilitate renal engraftment; therefore, immunostaining for FoxP3(+) Treg in patients with SCR on protocol biopsies may ultimately be useful to identify patients who may require alterations in their immunosuppressive regimens.